Archives of Virology

, Volume 152, Issue 7, pp 1375–1381

Prevalence of antibody to hepatitis E virus among wild sika deer, Cervus nippon, in Japan

  • Y. Matsuura
  • M. Suzuki
  • K. Yoshimatsu
  • J. Arikawa
  • I. Takashima
  • M. Yokoyama
  • H. Igota
  • K. Yamauchi
  • S. Ishida
  • D. Fukui
  • G. Bando
  • M. Kosuge
  • H. Tsunemitsu
  • C. Koshimoto
  • K. Sakae
  • M. Chikahira
  • S. Ogawa
  • T. Miyamura
  • N. Takeda
  • T. C. Li
Brief Report

Summary

We examined 976 sika deer serum samples, 159 liver tissue samples and 88 stool samples collected from 16 prefectures in Japan, and performed ELISA and RT-PCR assays to detect antibodies to HEV and HEV RNA, respectively. Although 25 (2.6%) of 976 samples were positive for anti-HEV IgG, the antibody titers were very low. The OD values ranged between 0.018 and 0.486, forming a single distribution rather than a bimodal distribution, suggesting that the antibody detected in this study was not induced by HEV infection, or that deer have low sensitivity to HEV. HEV RNA was not detected in these samples, also suggesting that deer may not play a role as an HEV reservoir.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Y. Matsuura
    • 1
  • M. Suzuki
    • 2
  • K. Yoshimatsu
    • 1
  • J. Arikawa
    • 1
  • I. Takashima
    • 3
  • M. Yokoyama
    • 4
  • H. Igota
    • 5
  • K. Yamauchi
    • 6
  • S. Ishida
    • 7
  • D. Fukui
    • 8
  • G. Bando
    • 8
  • M. Kosuge
    • 8
  • H. Tsunemitsu
    • 9
  • C. Koshimoto
    • 10
  • K. Sakae
    • 11
  • M. Chikahira
    • 12
  • S. Ogawa
    • 13
  • T. Miyamura
    • 13
  • N. Takeda
    • 13
  • T. C. Li
    • 13
  1. 1.Institute for Animal Experimentation, Graduate School of MedicineHokkaido UniversitySapporoJapan
  2. 2.Laboratory of Wildlife Biology, Department of Environmental Veterinary Science, Graduate School of Veterinary MedicineHokkaido UniversitySapporoJapan
  3. 3.Laboratory of Public Health, Department of Environmental Veterinary Science, Graduate School of Veterinary MedicineHokkaido UniversitySapporoJapan
  4. 4.Museum of Human and Nature ActivitiesHyogoJapan
  5. 5.Nishiokoppe Wildlife AssociationHokkaidoJapan
  6. 6.Research Institute for Environmental Sciences and Public Health of Iwate PrefectureMoriokaJapan
  7. 7.Enterovirology Division, Department of MicrobiologyHokkaido Institute of Public HealthSapporoJapan
  8. 8.Asahikawa Zoological Park and Wildlife Conservation CenterAsahikawaJapan
  9. 9.Research Team for Viral Diseases, National Institute of Animal HealthIbaragiJapan
  10. 10.Department of Bio-resources, Division of Biotechnology, Frontier Science Research CenterUniversity of MiyazakiMiyazakiJapan
  11. 11.Department of MicrobiologyAichi Prefectural Institute of Public HealthNagoyaJapan
  12. 12.Infectious Diseases Research DivisionHyogo Prefecture Institute of Public Heath and Environmental ScienceKobeJapan
  13. 13.Department of Virology IINational Institute of Infectious DiseasesTokyoJapan

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