Archives of Virology

, Volume 152, Issue 6, pp 1201–1208

Molecular phylogeny of modern coxsackievirus A16

  • D. Perera
  • M. A. Yusof
  • Y. Podin
  • M. H. Ooi
  • N. T. T. Thao
  • K. K. Wong
  • A. Zaki
  • K. B. Chua
  • Y. A. Malik
  • P. V. Tu
  • N. T. K. Tien
  • P. Puthavathana
  • P. C. McMinn
  • M. J. Cardosa
Brief Report

Summary.

A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7–30.2% and 19.9–25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • D. Perera
    • 1
  • M. A. Yusof
    • 1
    • 2
  • Y. Podin
    • 1
  • M. H. Ooi
    • 1
    • 3
  • N. T. T. Thao
    • 4
  • K. K. Wong
    • 5
  • A. Zaki
    • 6
  • K. B. Chua
    • 7
  • Y. A. Malik
    • 5
    • 8
  • P. V. Tu
    • 4
  • N. T. K. Tien
    • 4
  • P. Puthavathana
    • 9
  • P. C. McMinn
    • 10
  • M. J. Cardosa
    • 1
  1. 1.Institute of Health and Community MedicineUniversiti Malaysia SarawakSarawakMalaysia
  2. 2.Institute for Medical ResearchKuala LumpurMalaysia
  3. 3.Sibu HospitalSarawakMalaysia
  4. 4.Pasteur InstituteHo Chi Minh CityVietnam
  5. 5.Faculty of MedicineUniversiti Kebangsaan MalaysiaMalaysia
  6. 6.Dr. Fakeeh HospitalJeddahSaudi Arabia
  7. 7.National Public Health LaboratorySungai BulohMalaysia
  8. 8.International Medical UniversityKuala LumpurMalaysia
  9. 9.Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand
  10. 10.Telethon Institute for Child Health ResearchPerthWestern Australia

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