Molecular phylogeny of modern coxsackievirus A16 Brief Report First Online: 19 February 2007 Received: 14 November 2006 Accepted: 21 December 2006 DOI:
Cite this article as: Perera, D., Yusof, M., Podin, Y. et al. Arch Virol (2007) 152: 1201. doi:10.1007/s00705-006-0934-5 Summary.
A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7–30.2% and 19.9–25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.
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