Archives of Virology

, 152:533 | Cite as

Race: a risk factor for dengue hemorrhagic fever

  • B. de la C. Sierra
  • G. Kourí
  • M. G. Guzmán
Article

Summary.

Cuban DHF/DSS outbreaks have provided evidence of a reduced risk of people of Negroid race for DHF/DSS compared to those of Caucasoid race. These observations from Cuban dengue outbreaks have significant epidemiological interest, as the differences in susceptibility to DHF/DSS among racial groups in Cuba coincide with that reported in African and Black Caribbean populations. In this article, we review the literature on race as a risk factor for DHF/DSS and discuss recent results from onging studies. Taking into consideration the origins of contemporary Cuban inhabitants, we propose that the Cuban, Caribbean Black and African populations share a common gene pool that could explain, at least partially, the low incidence of dengue hemorrhagic fever in Cuba and Caribbean and African countries. The central role played by immunological mechanisms in the pathogenesis of DHF/DSS has led us to consider that the polymorphic genes associated with the immune response must be carefully considered among those human genes regulating dengue disease severity that might be distributed unequally in Blacks and Whites.

References

  1. Agramonte A (1906) Notas clínicas sobre una epidemia reciente de dengue. Rev Med Cir (Cuba) January: 222–226Google Scholar
  2. Benenson, AS 1990Control of communicable diseases in man15American Public Health AssociationBaltimore, MDGoogle Scholar
  3. Blackwell, JM 2001Genetics and genomics in infectious disease susceptibilityTrends Microbiol7521526Google Scholar
  4. Bravo, JR, Guzmán, MG, Kourí, GP 1987Why dengue haemorrhagic fever in Cuba? I. Individual risk factors for dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS)Trans R Soc Trop Med Hyg81816820PubMedCrossRefGoogle Scholar
  5. Bruck S (1981) España en la población del mundo. Prontuario etnodemográfico. Editorial de Ciencias, MoscúGoogle Scholar
  6. Carrington, M 1999HLA and HIV-1: Heterozygote advantage and B*35-CW*04 disadvantageScience28317481752PubMedCrossRefGoogle Scholar
  7. Cavalli-Sforza, LL, Bodmer, WF 1999a

    Quantitative characters, polygenic inheritance and environmental factors

    Cavalli-Sforza, LLBodmer, WF eds. The genetics of human populationDover Publ.Mineola, New York9.19.14
    Google Scholar
  8. Cavalli-Sforza, LL, Bodmer, WF 1999b

    Genetic demography and natural selection

    Cavalli-Sforza, LLBodmer, WF eds. The genetics of human populationDover Publ.Mineola, New York6.16.9
    Google Scholar
  9. Cavalli-Sforza, LL, Bodmer, WF 1999c

    Human evolution

    Cavalli-Sforza, LLBodmer, WF eds. The genetics of human populationDover Publ.Mineola, New York11.111.11
    Google Scholar
  10. Censo de Población y Viviendas (2002) Oficina Nacional de Estadistica Poblacional Cuba. http://www.cubagob.cu/otras_info/censo/index.htm
  11. Centro de Estudios Demográficos Cubanos (1976) La Población de Cuba. Editorial Ciencias Sociales, La Habana, CubaGoogle Scholar
  12. Diaz, A, Kourí, G, Guzmán, MG, Lobaina, L, Bravo, J, Ruiz, A 1988Description of the clinical picture of dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS) in adultsBull Pan Am Health Org22133144Google Scholar
  13. Gonzalez, D, Castro, OE, Kourí, G, Perez, J, Martinez, E, Vazquez, S, Rosario, D, Cancio, R, Guzmán, MG 2005Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001–2002Int J Inf Dis9280285CrossRefGoogle Scholar
  14. Green, S, Vaughn, DW, Kalayanarooj, S, Nimmannitya, S, Suntayakorn, S, Nisalak, A, Lew, R, Innis, BL, Kurane, I, Rothman, AL, Ennis, FA 1999Early activation in acute dengue is related to development of plasma leakage and disease severityJ Infect Dis179755762PubMedCrossRefGoogle Scholar
  15. Gubler, DJ 1997

    Dengue and dengue hemorrhagic fever: its history and resurgence as a global public health problem

    Gubler, DJKuno, G eds. Dengue and dengue hemorrhagic feverCAB International PressNew York129
    Google Scholar
  16. Gubler, DJ 1998The global pandemic of dengue/dengue hemorrhagic fever: current status and prospects for the futureAnn Acad Med Singapore27227234PubMedGoogle Scholar
  17. Gubler, DJ, Meltzer, M 1999Impact of dengue/dengue hemorrhagic fever on the developing worldAdv Virus Res533570PubMedCrossRefGoogle Scholar
  18. Gubler, DJ, Sather, GE, Kuno, G, Cabarl, JR 1986Dengue 3 transmission in AfricaAm J Trop Med Hyg3512801284PubMedGoogle Scholar
  19. Guerra R (1964) Manual de Historia de Cuba desde su descubrimiento. Colección Histórica, Editorial Nacional de Cuba, La Habana, CubaGoogle Scholar
  20. Guzmán, MG, Kourí, GP, Bravo, J, Soler, M, Vazquez, S, Morier, L 1990Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic studyAm J Med Hyg42179184Google Scholar
  21. Guzmán, MG, Kourí, GP, Vazquez, S, Rosario, D, Bravo, JR, Valdez, L 1999aDHF epidemics in Cuba, 1981 and 1987: Some interesting observationsDengue Bull WHO233943Google Scholar
  22. Guzmán, MG, Alvarez, M, Rodriguez, R, Rosario, D, Vazquez, S, Valdes, L 1999bFatal dengue hemorrhagic fever in CubaInt J Infect Dis3130135CrossRefGoogle Scholar
  23. Guzmán, MG, Kourí, G, Valdéz, L, Bravo, J, Álvarez, M, Vázquez, S, Delgado, I, Halstead, SB 2000Epidemiological studies of dengue in Santiago de Cuba, 1997Am J Epid152793799CrossRefGoogle Scholar
  24. Guzmán, MG, Kourí, G, Valdéz, L, Bravo, J, Vazquez, S, Halstead, SB 2002Enhanced severity of secondary dengue 2 infection occurring at an interval of 20 compared with 4 years after dengue 1 infectionRev Pan S Publ11223227Google Scholar
  25. Halstead, SB 1997

    Epidemiology of dengue and dengue hemorrhagic fever

    Gubler, DJKuno, G eds. Dengue and dengue hemorrhagic feverCAB International PressNew York2345
    Google Scholar
  26. Halstead, SB 1988Pathogenesis of dengue. Challenge to molecular biologyScience239476481PubMedCrossRefGoogle Scholar
  27. Halstead, SB, Streit, TG, Lafontant, JG, Putvatana, P, Russell, K, Sun, W, Kanesa-Thasan, N, Hayes, CG, Watts, DM 2001Haiti: absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmissionAm J Med Hyg65180183Google Scholar
  28. Kourí, GP, Guzmán, MG, Bravo, JR, Triana, C 1989Dengue hemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemicBull Pan Am Health Organ67375380Google Scholar
  29. Kourí, G, Guzmán, MG, Valdés, L, Carbonel, I, del Rosario, D, Vázquez, S, Laferté, J, Delgado, J, Cabrera, MV 1998Reemergence of dengue in Cuba: a 1997 epidemic in Santiago de CubaEmerg Infect Dis48992PubMedCrossRefGoogle Scholar
  30. Kurane, I, Ennis, FA 1992Immunity and immunopathology in dengue infectionsSemin Immunol4121127PubMedGoogle Scholar
  31. Kurane, I, Takasaki, T 2001Dengue fever and dengue hemorrhagic fever: challenges of controlling an enemy still at largeRev Med Virol11301311PubMedCrossRefGoogle Scholar
  32. Martin, R, Saller, K 1957Lehrbuch der AnthropologieG. FischerStuttgartGoogle Scholar
  33. McBride, WJ, Bielefeldt-Ohmann, H 2000Dengue viral infections; pathogenesis and epidemiologyMicrobes Infect210411050PubMedCrossRefGoogle Scholar
  34. Messer, WB, Gubler, DJ, Harris, E, Sivananthan, K, de Silva, AM 2003Emergence and global spread of a dengue serotype 3, subtype III virusEmerg Infect Dis9800809PubMedGoogle Scholar
  35. Modiano, D 1996Different response to Plasmodium falciparum malaria in West African sympatric ethnic groupsProc Natl Acad Sci USA931320613211PubMedCrossRefGoogle Scholar
  36. Moreria LM, Ustariz C, Garcia MA (2005) Frecuencia de antígenos HLA en la población cubana, según características étnicas. Rev Cubana Hematol Inmunol Hemoter 21(2)Google Scholar
  37. Morier, L, Kourí, G, Guzmán, MG, Soler, M 1987Antibody-dependent enhancement of dengue 2 virus in people of White descent in CubaThe Lancet, May210281029CrossRefGoogle Scholar
  38. Pan American Health Organization (PAHO)1992Dengue and dengue hemorrhagic fever in the Americas: an overview of the problemEpidemiol Bull13910Google Scholar
  39. Pelaez, O, Guzmán, MG, Kourí, G, Perez, R, San Martin, JL, Vazquez, S, Rosario, D, Mora, R, Quintana, I, Bisset, J, Cancio, R, Masa, AM, Castro, O, Gonzalez, D, Avila, LC, Rodriguez, R, Alvarez, M, Pelegrino, JL, Bernardo, L, Prado, I 2004Dengue 3 epidemic, Havana, 2001Emerg Infect Dis10719722PubMedGoogle Scholar
  40. Pérez, AB, García, G, Sierra, B, Alvarez, M, Vázquez, S, Cabrera, MV, Rodríguez, R, Rosario, D, Martínez, E, Denny, T, Guzmán, MG 2004IL-10 levels in dengue patients. Some findings from the exceptional epidemiological conditions of CubaJ Med Virol73230234PubMedCrossRefGoogle Scholar
  41. Pospisil MF (1965) Manual de prácticas de antropología física. Editorial Nacional de Cuba, Habana, Cuba, pp 163–173Google Scholar
  42. Rivero de la Calle M (1984) Antropología de la población adulta Cubana. Editorial Científico Técnica, La Habana, Cuba, pp 28–32Google Scholar
  43. Roche, JC, Cordellier, E, Hervy, JP, Digoutte, JP, Monteny, N 1983Isolement de 96 souchess de virus dengue a partir de moustiques captures en Cote D’Ivoire et Haute-VoltaAnn Virol (Ins Pasteur)134E233244CrossRefGoogle Scholar
  44. Rothman, AL 1997

    Viral pathogenesis of dengue infections

    Gubler, DJKuno, G eds. Dengue and dengue hemorrhagic feverCAB International PressNew York245273
    Google Scholar
  45. Rothman, AL, Ennis, FA 1999Immunopathogenesis of dengue hemorrhagic feverVirology25716PubMedCrossRefGoogle Scholar
  46. Saluzzo, JF, Cornet, M, Castaneg, P, Rey, C, Digoutte, JP 1986Isolation of dengue 2 and dengue 4 viruses from patients in SenegalTrans R Soc Trop Med Hyg805PubMedCrossRefGoogle Scholar
  47. Segal, S, Hill, AVS 2003Genetic susceptibility to infectious diseasesTrends Microbiol11445448PubMedCrossRefGoogle Scholar
  48. Sharp, TW, Wallace, MR, Hayes, CG, Sanchez, JL, DeFraites, RF, Arthur, RR, Thornton, SA, Batchelor, RA, Rozmajzl, PJ, Hanson, RK, Wu, SJ, Iriye, C, Burans, JP 1995Dengue fever in U.S. troops during Operation Restore Hope, Somalia, 1992–1993Am J Trop Med Hyg538994PubMedGoogle Scholar
  49. Sierra, B, García, G, Pérez, AB, Morier, L, Alvarez, M, Kourí, G, Guzmán, MG 2006Ethnicity and difference in dengue virus-specific memory T cell responses in Cuban individualsViral Immunol194CrossRefGoogle Scholar
  50. Thursz, MR 1997Heterozygote advantage for HLA class II type in hepatitis B virus infectionNat Genet171112PubMedCrossRefGoogle Scholar
  51. Ulloa J (2002) Archaeology and Rescue of the Aboriginal Presence in Cuba and the Caribbean. KACIKE: The Journal of Caribbean Amerindian History and Anthropology [On-line Journal], Special Issue, Available at: http://www.kacike.org/UlloaEnglish.html
  52. Valdéz, L, Guzmán, MG, Kourí, G, Delgado, J, Carbonell, I, Cabrera, MV, Rosario, D, Vazquez, S 1997The epidemiology of dengue and dengue hemorrhagic fever in Santiago de CubaPan Am J Publ Health61625Google Scholar
  53. Williams, S 1994Cuba: the land, the history, the people, the cultureRunning Press Book PublPennsylvaniaGoogle Scholar
  54. Wolpoff, M, Caspari, R 1997Race and human evolutionSimon and SchusterNew YorkGoogle Scholar
  55. World Health Organization (1999) Prevention and control of dengue and dengue haemorrhagic fever. WHO Regional Publication, SEARO No. 29, New Delhi, IndiaGoogle Scholar
  56. Wright, IA 1916The early history of Cuba 1492–1586Macmillan CNew YorkGoogle Scholar
  57. Zeller, HG 1998Dengue, arbovirus and migrations in the Indian OceanBull Soc Pathol Exot915660PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • B. de la C. Sierra
    • 1
  • G. Kourí
    • 1
  • M. G. Guzmán
    • 1
  1. 1.Department of VirologyInstitute for Tropical Medicine “Pedro Kourí”HabanaCuba

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