Archives of Virology

, Volume 151, Issue 10, pp 2047–2053

The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction

  • L. Wang
  • L. Shan
  • J. Yin
  • M. Zhao
  • D. Su
  • J. Zhong
Brief Report

Summary.

A baculoviral mammalian-cell vector was constructed to express Rta, a protein of Epstein-Barr virus (EBV) responsible for the transition from latent infection to lytic replication. EBV lytic replication and cell-growth inhibition was observed in infected D98/HR1 cells. The baculovirus caused little cytotoxicity in the non-targeted HeLa cells, compared to an adenovirus vector. It is concluded that recombinant baculovirus might have the potential as a vector for the therapy of EBV-related cancer.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • L. Wang
    • 1
  • L. Shan
    • 1
  • J. Yin
    • 1
  • M. Zhao
    • 1
  • D. Su
    • 1
  • J. Zhong
    • 1
  1. 1.Department of Microbiology and Microbial Engineering, School of Life SciencesFudan UniversityShanghaiP.R. China

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