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Archives of Virology

, Volume 151, Issue 6, pp 1225–1233 | Cite as

Human cytomegalovirus UL131A, UL130 and UL128 genes are highly conserved among field isolates

  • F. Baldanti
  • S. Paolucci
  • G. Campanini
  • A. Sarasini
  • E. Percivalle
  • M. G. Revello
  • G. Gerna
Brief Report

Summary.

Coding sequences of the UL131A, UL130, and UL128 genes of human cytomegalovirus (HCMV) were found to be highly conserved among 34 field isolates from pregnant women with primary HCMV infection and their fetuses or newborns, as well as from solid organ transplant recipients and patients with AIDS. No strain clustering was observed. In contrast, sequencing of UL55 (gB coding gene) allowed the 34 isolates to be clustered into 4 genotypes. The conservation of the UL131A-UL128 locus is consistent with the conclusion that the three encoded proteins are all essential for growth of HCMV in endothelial cells and virus transfer to leukocytes.

Keywords

Endothelial Cell Infectious Disease Pregnant Woman Transplant Recipient Code Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • F. Baldanti
    • 1
  • S. Paolucci
    • 1
  • G. Campanini
    • 1
  • A. Sarasini
    • 1
  • E. Percivalle
    • 1
  • M. G. Revello
    • 1
  • G. Gerna
    • 1
  1. 1.Servizio di Virologia, IRCCS Policlinico San MatteoPaviaItaly

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