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Archives of Virology

, Volume 150, Issue 11, pp 2299–2311 | Cite as

Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia

  • P. C. Y. Woo
  • S. K. P. Lau
  • Y. Huang
  • H.-W. Tsoi
  • K.-H. Chan
  • K.-Y. Yuen
Article

Summary.

Phylogenetic trees constructed using predicted amino acid sequences of putative proteins of coronavirus HKU1 (CoV-HKU1) revealed that CoV-HKU1 formed a distinct branch among group 2 coronaviruses. Of the 14 trees from p65 to nsp10, nine showed that CoV-HKU1 was clustered with murine hepatitis virus. From nsp11, the topologies of the trees changed dramatically. For the eight trees from nsp11 to N, seven showed that the CoV-HKU1 branch was the first branch. The codon usage patterns of CoV-HKU1 differed significantly from those in other group 2 coronaviruses. Split decomposition analysis revealed that recombination events had occurred between CoV-HKU1 and other coronaviruses.

Keywords

Hepatitis Codon Infectious Disease Pneumonia Amino Acid Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • P. C. Y. Woo
    • 1
    • 2
    • 3
  • S. K. P. Lau
    • 1
    • 2
    • 3
  • Y. Huang
    • 1
  • H.-W. Tsoi
    • 1
  • K.-H. Chan
    • 1
  • K.-Y. Yuen
    • 1
    • 2
    • 3
  1. 1.Department of Microbiology, Faculty of MedicineThe University of Hong KongHong Kong
  2. 2.Research Centre of Infection and Immunology, Faculty of MedicineThe University of Hong KongHong Kong
  3. 3.State Key Laboratory of Emerging Infectious Diseases, The University of Hong KongHong Kong

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