Archives of Virology

, Volume 150, Issue 9, pp 1927–1931 | Cite as

Rotavirus antigenemia in children with encephalopathy accompanied by rotavirus gastroenteritis

  • T. Nakagomi
  • O. Nakagomi
Rapid Communication


Rotavirus antigen was detected in acute phase sera from 5 of 8 children with rotavirus-associated encephalopathy, confirming antigenemia. However, antigen was not detected in cerebrospinal fluid, failing to provide added evidence of invasion to the brain.


Infectious Disease Cerebrospinal Fluid Acute Phase Gastroenteritis Acute Phase Seron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Blutt, SE, Kirkwood, CD, Parreno, V, Warfield, KL, Ciarlet, M, Estes, MK, Bok, K, Bishop, RF, Conner, ME 2003Rotavirus antigenaemia and viraemia: a common event?Lancet36214451449CrossRefPubMedGoogle Scholar
  2. Gouvea, V, Glass, RI, Woods, P, Taniguchi, K, Clark, HF, Forrester, B, Fang, Z 1990Polymerase chain reaction amplification and typing of rotavirus nucleic acid from stool specimens.J Clin Microbiol28276282PubMedGoogle Scholar
  3. Kapikian AZ, Hoshino Y, Chanock RM (2001) Rotaviruses. In: Knipe DM, Howley PM (eds), Fields virology. Lippincott-Williams & Wilkins, Philadelphia, pp 1787–1833Google Scholar
  4. Lynch, M, Lee, B, Azimi, P, Gentsch, J, Glaser, C, Gilliam, S, Chang, HG, Ward, R, Glass, RI 2001Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review.Clin Infect Dis33932938CrossRefPubMedGoogle Scholar
  5. Mossel, EC, Ramig, RF 2002Rotavirus genome segment 7 (NSP3) is a determinant of extraintestinal spread in the neonatal mouse.J Virol7665026509CrossRefPubMedGoogle Scholar
  6. Mossel, EC, Ramig, RF 2003A lymphatic mechanism of rotavirus extraintestinal spread in the neonatal mouse.J Virol771235212356CrossRefPubMedGoogle Scholar
  7. Uhnoo, I, Riepenhoff-Talty, M, Dharakul, T, Chegas, P, Fisher, JE, Greenberg, HB, Ogra, PL 1990Extramucosal spread and development of hepatitis in immunodeficient and normal mice infected with rhesus rotavirus.J Virol64361368PubMedGoogle Scholar
  8. Ushijima, H, Xin, KQ, Nishimura, S, Morikawa, S, Abe, T 1994Detection and sequencing of rotavirus VP7 gene from human materials (stools, sera, cerebrospinal fluids, and throat swabs) by reverse transcription and PCR.J Clin Microbiol3228932897PubMedGoogle Scholar
  9. Yoshida, A, Kawamitu, T, Tanaka, R, Okumura, M, Yamakura, S, Takasaki, Y, Hiramatsu, H, Momoi, T, Iizuka, M, Nakagomi, O 1995Rotavirus encephalitis: detection of the virus genomic RNA in the cerebrospinal fluid of a child.Pediatr Infect Dis J14914916PubMedGoogle Scholar
  10. Goldwater, PN, Rowland, K, Power, R, Thesinger, M, Abbott, K, Grieve, A, Palombo, EA, Masendycz, PJ, Wilkinson, I, Bear, J 2001Rotavirus encephalopathy: pathogenesis reviewed.J Paediatr Child Health37206209CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • T. Nakagomi
    • 1
  • O. Nakagomi
    • 2
  1. 1.Department of MicrobiologyAkita University School of MedicineAkitaJapan
  2. 2.Department of Molecular Microbiology and ImmunologyGraduate School of Biomedical Sciences, Nagasaki UniversityNagasakiJapan

Personalised recommendations