Archives of Virology

, Volume 150, Issue 9, pp 1693–1713 | Cite as

Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties

  • P. Kaukinen
  • A. Vaheri
  • A. Plyusnin
Brief Review


In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these “house keeping” duties, the N protein performs interactive “ambassadorial” functions interfering with important regulatory pathways in the infected cells.


Infectious Disease Macromolecule Infected Cell Structural Component Regulatory Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • P. Kaukinen
    • 1
  • A. Vaheri
    • 1
  • A. Plyusnin
    • 1
  1. 1.Department of VirologyHaartman Institute, University of HelsinkiFinland

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