Archives of Virology

, Volume 150, Issue 9, pp 1693–1713

Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties

  • P. Kaukinen
  • A. Vaheri
  • A. Plyusnin
Brief Review

DOI: 10.1007/s00705-005-0555-4

Cite this article as:
Kaukinen, P., Vaheri, A. & Plyusnin, A. Arch Virol (2005) 150: 1693. doi:10.1007/s00705-005-0555-4

Summary.

In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these “house keeping” duties, the N protein performs interactive “ambassadorial” functions interfering with important regulatory pathways in the infected cells.

Copyright information

© Springer-Verlag/Wien 2005

Authors and Affiliations

  • P. Kaukinen
    • 1
  • A. Vaheri
    • 1
  • A. Plyusnin
    • 1
  1. 1.Department of VirologyHaartman Institute, University of HelsinkiFinland

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