Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties
- First Online:
- Cite this article as:
- Kaukinen, P., Vaheri, A. & Plyusnin, A. Arch Virol (2005) 150: 1693. doi:10.1007/s00705-005-0555-4
In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these “house keeping” duties, the N protein performs interactive “ambassadorial” functions interfering with important regulatory pathways in the infected cells.