Journal of Neural Transmission

, Volume 109, Issue 3, pp 267–277

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons

  • L. M. Farkas
  • K. Krieglstein

Summary.

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF-family of ligands signaling via the EGF-receptor tyrosine kinase. In the present study we show that HB-EGF which is expressed in close proximity of developing mesencephalic dopaminergic neurons promotes the survival of TH-positive neurons in vitro. The survival promoting effect of HB-EGF is mediated via astroglial cells and utilizes the MAPK as well as the Akt-signaling pathway. Most notably endogenous HB-EGF significantly contributes to the survival of TH-+ neurons in control cultures, suggesting a relevant developmental role of HB-EGF for dopaminergic neurons. These findings indicate that HB-EGF may be an important molecule for developing dopaminergic neurons of the ventral midbrain.

Keywords: Dopaminergic neurons neurotrophic factors Parkinson's disease (PD) EGF TGF-α. 

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Copyright information

© Springer-Verlag Wien 2002

Authors and Affiliations

  • L. M. Farkas
    • 1
  • K. Krieglstein
    • 2
  1. 1.Neuroanatomy, University of Heidelberg, Heidelberg, andDE
  2. 2.Department of Anatomy and Cell Biology, University of Saarland, Homburg/Saar, Federal Republic of GermanyDE

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