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Journal of Neural Transmission

, Volume 109, Issue 2, pp 213–218 | Cite as

Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders

  • H. Kunugi
  • T. Kato
  • R. Fukuda
  • M. Tatsumi
  • T. Sakai
  • S. Nanko
Short Communication

Summary.

Alterations of G proteins have been implicated in major psychiatric illnesses. A C825T polymorphism of a gene encoding the β3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder. We examined whether this polymorphism is associated with functional psychoses in a Japanese sample of 370 schizophrenics, 164 bipolars, 68 depressive patients, and 198 controls. We obtained no evidence for an association of the polymorphism with any diagnostic group.

Keywords: Schizophrenia mood disorder bipolar disorder unipolar depression association study polymorphism G-protein β3 subunit (GNB3) signal transduction. 

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Copyright information

© Springer-Verlag Wien 2002

Authors and Affiliations

  • H. Kunugi
    • 1
  • T. Kato
    • 2
  • R. Fukuda
    • 3
  • M. Tatsumi
    • 4
  • T. Sakai
    • 5
  • S. Nanko
    • 1
  1. 1.Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo,JP
  2. 2.Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama,JP
  3. 3.Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo,JP
  4. 4.Department of Psychiatry, Showa University Fujigaoka Hospital, Yokohama, andJP
  5. 5.Saitama Comprehensive Mental Health Center, Saitama, JapanJP

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