Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders
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Alterations of G proteins have been implicated in major psychiatric illnesses. A C825T polymorphism of a gene encoding the β3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder. We examined whether this polymorphism is associated with functional psychoses in a Japanese sample of 370 schizophrenics, 164 bipolars, 68 depressive patients, and 198 controls. We obtained no evidence for an association of the polymorphism with any diagnostic group.
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