Journal of Neural Transmission

, Volume 108, Issue 4, pp 489–495 | Cite as

An association of the polymorphic repeat of tetranucleotide (TCAT) in the first intron of the human tyrosine hydroxylase gene with schizophrenia in a Japanese sample

  • A. Kurumaji
  • T. Kuroda
  • K. Yamada
  • T. Yoshikawa
  • M. Toru

Summary.

Tyrosine hydroxylase (TH) is the rate limiting enzyme in the synthesis of dopamine and norepinephrine. A polymorphic repeat of the tetranucleotide (TCAT) in the first intron of the TH gene may behave as a regulatory element for the gene expression. Allelic fragments of the tandem repeat were typed by a PCR-based process with a pair of primers specific for the polymorphic sequence. The association between the polymorphism and schizophrenia was examined in a Japanese sample. There was a statistically significant association between the polymorphism and schizophrenia in females (χ2 = 26.018, p = 0.010), but not in males (χ2 = 15.995, p = 0.305). The genotype heterozygous for the TH9 and TH6 was significantly decreased in female schizophrenics (χ2 = 5.125, p = 0.0236). These results suggest that TH could be considered as a minor gene contributing to the susceptibility of Japanese female schizophrenia.

Keywords: Tyrosine hydroxylase gene schizophrenia association tetranucleotide repeat gender difference. 

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Copyright information

© Springer-Verlag Wien 2001

Authors and Affiliations

  • A. Kurumaji
    • 1
  • T. Kuroda
    • 2
  • K. Yamada
    • 3
  • T. Yoshikawa
    • 3
  • M. Toru
    • 1
  1. 1.Department of Neuropsychiatry, and
  2. 2.School of Allied Health Sciences, Tokyo Medical and Dental University School of Medicine, Tokyo,
  3. 3.Laboratory for Molecular Psychiatry, Brain Science Institute, Riken, JapanJP

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