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Journal of Neural Transmission

, Volume 108, Issue 12, pp 1457–1474 | Cite as

Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain

  • T. Löffler
  • S. K. Lee
  • M. Nöldner
  • S. S. Chatterjee
  • S. Hoyer
  • R. Schliebs

Summary.

To reveal whether an extract of Ginkgo biloba (EGb761) may affect streptozotocin (STZ)-induced impairments in brain glucose metabolism, autoradiographies of [3H]cytochalasin-B binding to the total population of glucose transporters, [125I]insulin binding to insulin receptors, [3H]glyburide binding to sulfonylurea receptors, and radioactive in situ hybridization for GLUT3 mRNA were carried out in hippocampal brain sections of adult rats that have additionally been divided into good performers (GP) and poor performers (PP) by behavioural tests before the experiments. The STZ-induced increases in hippocampal [3H]cytochalasin-B binding to (total) glucose transporters returned to almost normal values following EGb761 treatment, regardless of the experimental animal group (GP or PP) tested. Similarly, the STZ-mediated enhancements in hippocampal insulin receptor binding of GP rats were partially compensated by the treatment with EGb761. The data suggest beneficial effects of EGb671 on impaired brain glucose metabolism, at least under the experimental conditions used in the study presented.

Keywords: Egb761, insulin receptor, sulfonyl urea binding, glucose transporter, in situ hybridization, autoradiography, streptotozotocin, rat hippocampus. 

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Copyright information

© Springer-Verlag Wien 2001

Authors and Affiliations

  • T. Löffler
    • 1
  • S. K. Lee
    • 2
  • M. Nöldner
    • 3
  • S. S. Chatterjee
    • 3
  • S. Hoyer
    • 2
  • R. Schliebs
    • 1
  1. 1.Paul Flechsig Institute for Brain Research, University of LeipzigDE
  2. 2.Department of Pathochemistry and General Neurochemistry, University of HeidelbergDE
  3. 3.Dr. Willmar Schwabe Arzneimittel, Karlsruhe, Federal Republic of GermanyDE

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