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Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis

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Summary.

To elucidate whether serum coenzyme Q10 levels are related with the risk for amyotrophic lateral sclerosis (ALS), we compared serum levels of coenzyme Q10 and the coenzyme Q10/cholesterol ratio, in 30 patients with ALS and 42 matched controls using a high performance liquid chromatography technique. The mean serum coenzyme Q10 levels and the coenzyme Q10/cholesterol ratio did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal vs. bulbar) of ALS, and they did not correlate with age, age at onset, and duration of the disease. These results suggest that serum coenzyme Q10 concentrations are unrelated with the risk for ALS.

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Authors and Affiliations

  1. Department of Neurology and, , , , ,

    J. A. Molina, C. Gómez-Escalonilla, J. Esteban, A. Martínez-Salio & G. Ruiz Indurain

  2. Department of Biochemistry, Hospital Universitario Doce de Octubre,, , , , ,

    F. de Bustos, A. García-Redondo, P. del Hoyo & J. Arenas

  3. Department of Medicine-Neurology, University of Alcalá, Alcalá de Henares,, , , , ,

    F. J. Jiménez-Jiménez

  4. Service of Neurology, Hospital Universitario San Carlos, Madrid, Spain, , , , , , ES

    A. Guerrero-Sola & C. Ramírez-Ramos

Authors
  1. J. A. Molina
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  2. F. de Bustos
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  3. F. J. Jiménez-Jiménez
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  4. C. Gómez-Escalonilla
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  5. A. García-Redondo
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  6. J. Esteban
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  7. A. Guerrero-Sola
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  8. P. del Hoyo
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  9. A. Martínez-Salio
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  10. C. Ramírez-Ramos
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  11. G. Ruiz Indurain
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  12. J. Arenas
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Received September 1, 1999; accepted January 4, 2000

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Molina, J., de Bustos, F., Jiménez-Jiménez, F. et al. Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis. J Neural Transm 107, 1021–1026 (2000). https://doi.org/10.1007/s007020070050

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  • DOI: https://doi.org/10.1007/s007020070050

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