Journal of Neural Transmission

, Volume 107, Issue 8, pp 997–1008

ECT in Parkinson's disease – dopamine transporter visualised by [123I]-β-CIT SPECT

  • P.-A. Fall
  • S. Ekberg
  • A.-K. Granérus
  • G. Granérus

DOI: 10.1007/s007020070048

Cite this article as:
Fall, PA., Ekberg, S., Granérus, AK. et al. J Neural Transm (2000) 107: 997. doi:10.1007/s007020070048

Summary.

Parkinson's disease (PD) is characterised by a loss of dopaminergic neurones in the basal ganglia. These neurones may be visualised by single photon emission computed tomography (SPECT) with the cocaine analogue 2β-carboxymethyl-3-β-(4-iodophenyl)tropane ([123I]β-CIT), which labels the dopamine reuptake sites in the nerve terminals. In order to evaluate the possibility to predict the outcome of ECT a prospective study was per-formed with six PD patients in whom the [123I]β-CIT uptake was measured before and after an electroconvulsive therapy (ECT) series. The side-to-side difference in the radiotracer uptake was found to be significantly lower in striatum located contralaterally to the part of the body with the most pronounced symptomathology. No significant change in uptake of the radioligand was seen after ECT. Patients with best uptake and thus with less advanced PD improved most after ECT. The possibility to use the [123I]β-CIT uptake to predict the outcome of ECT treatment has to be further evaluated.

Keywords: Parkinson's disease electroconvulsive therapy single photon emission computerized tomography (SPECT) [123I]β-CIT. 

Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • P.-A. Fall
    • 1
  • S. Ekberg
    • 2
  • A.-K. Granérus
    • 1
  • G. Granérus
    • 2
  1. 1.Division of Geriatrics, Department of Neuroscience and Locomotion, and
  2. 2.Division of Nuclear Medicine, Department of Medicine and Care, Faculty of Health Sciences, Linköping University, SwedenSE

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