Journal of Neural Transmission

, Volume 106, Issue 7–8, pp 787–794 | Cite as

Left temporal rhythmic electrical activity: a correlate for psychosis? A case report

  • M. Seeck
  • C. Alberque
  • L. Spinelli
  • C. M. Michel
  • P. Jallon
  • N. de Tribolet
  • T. Landis

Summary.

It is well recognized that epileptic patients are at higher risk for acute or chronic psychotic states than non-epileptic subjects. Here we present intracranial depth electrode recordings during a psychotic episode in a 20-year-old woman who was referred for presurgical evaluation. Unrelated to her seizures, she presented acoustic hallucinations and delusions and became agitated for a duration of 18–24 hours. During this period, a new unusual pattern of sharp slow waves was seen semi-rhythmically every 2–3sec from left anterior neocortical temporal areas. Her condition responded well to a treatment with Haloperidol, but not with Benzodiazepines. Ictal and interictal scalp- and depth-EEG recordings outside the psychotic episode as well as MRI-based volumetry, PET, SPECT and neuropsychological testing gave evidence of bilateral temporal and frontal dysfunction. This case report suggests that psychosis in epileptic patients may be based on a bilateral cerebral dysfunction linked together in a pathological network, but with a focal (here: left temporal) driving mechanism.

Keywords: Epilepsy psychosis EEG depth electrodes intracranial recordings auditory hallucinations human. 

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Copyright information

© Springer-Verlag Wien 1999

Authors and Affiliations

  • M. Seeck
    • 1
  • C. Alberque
    • 2
  • L. Spinelli
    • 1
  • C. M. Michel
    • 1
  • P. Jallon
    • 1
  • N. de Tribolet
    • 3
  • T. Landis
    • 1
  1. 1.Departments of Neurology and
  2. 2.Psychiatry, University Hospital of Geneva, and
  3. 3.Department of Neurosurgery, University Hospitals of Geneva and Lausanne, SwitzerlandCH

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