Journal of Neural Transmission

, Volume 105, Issue 10–12, pp 1229–1236

Amantadine attenuates response alterations resulting from repetitive L-DOPA treatment in rats

  • M. Karcz-Kubicha
  • G. Quack
  • W. Danysz

Summary.

It has been shown that NMDA receptor antagonists can inhibit both the development and expression of a decrease in the duration of L-DOPA action in rats rotating after unilateral lesion of the nigro-striatal dopaminergic system. Using this model we found that the low affinity NMDA receptor antagonist amantadine (50 mg/kg b.i.d.) attenuated both the expression and development of the shortening of duration of L-DOPA (25 mg/kg b.i.d.) action. Amantadine was most efficient when given both during the induction and expression phase. However, an additional interaction experiment demonstrated that acutely given amantadine also prolongs the duration of L-DOPA-induced rotations. Hence, only the effect on development of shortening of L-DOPA action can be regarded as specific for repetitive treatment mode. The data suggest that treatment with amantadine might have beneficial effects on response fluctuations produced by chronic L-DOPA treatment.

Keywords: Amantadine L-DOPA-response fluctuations rotations rats. 

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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • M. Karcz-Kubicha
    • 1
  • G. Quack
    • 1
  • W. Danysz
    • 1
  1. 1.Department of Pharmacological Research, Merz + Co., Frankfurt/M, Federal Republic of GermanyDE

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