Journal of Neural Transmission

, Volume 105, Issue 4–5, pp 497–505 | Cite as

Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease

  • F. J. Jiménez-Jiménez
  • J. A. Molina
  • M. V. Aguilar
  • I. Meseguer
  • C. J. Mateos-Vega
  • M. J. González-Muñoz
  • F. de Bustos
  • A. Martínez-Salio
  • M. Ortí-Pareja
  • M. Zurdo
  • M. C. Martínez-Para

Summary.

We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorption spectrophotometry, in 37 patients with Parkinson's disease (PD) and 37 matched controls. The CSF levels of zinc were significantly decreased in PD patients as compared with controls (p < 0.05). The serum levels of zinc, and the CSF and serum levels of iron, copper, and manganese, did not differ significantly between PD-patient and control groups.

There was no influence of antiparkinsonian therapy on CSF levels of none of these transition metals. These values were not correlated with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group, with the exception of CSF copper levels with the duration of the disease (r = 0.38, p < 0.05). These results suggest that low CSF zinc concentrations might be related with the risk for PD, although they could be related with oxidative stress processes.

Keywords: Parkinson's disease transition metals iron copper manganese zinc cerebrospinal fluid levels serum levels. 

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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • F. J. Jiménez-Jiménez
    • 1
  • J. A. Molina
    • 2
  • M. V. Aguilar
    • 4
  • I. Meseguer
    • 4
  • C. J. Mateos-Vega
    • 4
  • M. J. González-Muñoz
    • 4
  • F. de Bustos
    • 3
  • A. Martínez-Salio
    • 2
  • M. Ortí-Pareja
    • 1
  • M. Zurdo
    • 1
  • M. C. Martínez-Para
    • 4
  1. 1.Department of Neurology, Hospital Universitario "Príncipe de Asturias", Alcalá de Henares,
  2. 2.Department of Neurology and
  3. 3.Department of Biochemistry, Hospital Universitario Doce de Octubre, and
  4. 4.Department of Nutrition and Bromatology, Faculty of Pharmacy, University of Alcalá de Henares, Madrid, SpainES

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