Journal of Neural Transmission

, Volume 105, Issue 4–5, pp 415–422

Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis

  • S. Hoyer


The hypothesis is forwarded that sporadic late-onset Alzheimer disease is caused by non-insulin dependent diabetes mellitus which is confined to the brain. This hypothesis is based on the findings of Frölich and coworkers (this volume) who clearly demonstrate a perturbation of the neuronal insulin/insulin receptor signal transduction pathway which is considered to be the pathobiochemical basis for the drastic reduction in glucose/energy metabolism in Alzheimer brain. As a consequence of this abnormality, advanced glycation end products are formed. Münch et al. (this volume) evaluate the impacts of the latter related to oxidative stress and the formation of β-amyloid and neurofibrillary tangles.

Keywords: Sporadic Alzheimer disease brain insulin insulin receptor advanced glycation end products non-insulin dependent diabetes mellitus. 


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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • S. Hoyer
    • 1
  1. 1.Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Heidelberg, Federal Republic of GermanyDE

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