Journal of Neural Transmission

, Volume 105, Issue 1, pp 101–109 | Cite as

Insertion/deletion variant (−141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder

Short Communication

  • G. Stöber
  • S. Jatzke
  • A. Heils
  • G. Jungkunz
  • M. Knapp
  • R. Mössner
  • P. Riederer
  • K. P. Lesch

Summary.

A possible dysregulation of dopaminergic neurotransmission has been implicated in the aetiology of schizophrenic psychoses, in particular of paranoid-hallucinatory states, and of the manic episodes of bipolar affective disorder. In the present study we analysed allelic and genotypic variations of a recently described functional deletion/insertion variant (−141C Ins/Del) in the 59 flanking region of the human dopamine D2 receptor gene. We investigated a total of 620 unrelated individuals, comprising 260 schizophrenic patients, 70 patients with bipolar affective disorder, and 290 population controls. Analysis of the −141C Ins/Del variant revealed that the schizophrenic, bipolar affective and control groups did not differ significantly regarding genotype frequencies and allele frequencies. No evidence of an allelic association with either a family history of schizophrenic psychosis or a diagnosis of schizophrenia of the paranoid type (according to ICD 10) was found. Our findings indicate that the −141C Del variant in the 5′ flanking region of the human dopamine D2 receptor gene is unlikely to play a substantial role in genetic predisposition to major psychiatric disorders in Caucasians.

Keywords: Dopamine D2 receptor gene promoter polymorphism linkage schizophrenia bipolar affective disorder. 

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Copyright information

© Springer-Verlag Wien 1998

Authors and Affiliations

  • G. Stöber
    • 1
  • S. Jatzke
    • 1
  • A. Heils
    • 1
  • G. Jungkunz
    • 2
  • M. Knapp
    • 3
  • R. Mössner
    • 1
  • P. Riederer
    • 1
  • K. P. Lesch
    • 1
  1. 1.Department of Psychiatry, University of Würzburg, Würzburg,
  2. 2.State Mental Hospital, Lohr a.M., and
  3. 3.Institute for Medical Statistics, University of Bonn, Federal Republic of GermanyDE

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