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Journal of Neural Transmission

, Volume 126, Issue 12, pp 1695–1699 | Cite as

Macular ganglion-cell-complex layer thinning and optic nerve integrity in drug-naïve Parkinson’s disease

  • Jee-Young LeeEmail author
  • Jeeyun Ahn
  • Eun Jin Yoon
  • Sohee Oh
  • Yu Kyeong Kim
  • Beomseok Jeon
Neurology and Preclinical Neurological Studies - Short communication

Abstract

To reveal the macular inner retinal change linked to axonal degeneration in Parkinson’s disease (PD), we performed macular optical coherence tomography scan and diffusion tensor imaging of the retrobulbar optic nerve on both eyes of 36 drug-naïve PD patients. Thicknesses of inner retinal layers were automatically measured, and correlation analysis was conducted between the retinal thickness and diffusion parameters of the optic nerve. PD patients showed thinning of the inner retinal layers compared to control data. Thicknesses of the ganglion cell and inner plexiform layers were both correlated positively with fractional anisotropy and negatively with diffusivity indices of ipsilateral optic nerve (FDR-adjusted p < 0.05). This study revealed a novel in vivo connection between macular parafoveal ganglion cell change and integrity in the retrobulbar optic nerve in drug-naïve PD.

Keywords

Retina Macula Optic nerve Optical coherence tomography Diffusion tensor imaging Parkinson’s disease 

Notes

Funding

This work was supported by a National Research Foundation (NRF) grant funded by the Ministry of Education, Science and Technology (MEST) in Korea (NRF-2018R1C1B3008971) and by a clinical research grant-in-aid from the Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center (03-2015-8).

Compliance with ethical standards

Conflict of interest

J.-Y. Lee, J. Ahn, E. J. Yun, S. Oh, Y. K. Kim, and B. Jeon report there are no potential conflicts of interest related to this work.

Supplementary material

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Supplementary material 1 (TIFF 1623 kb)
702_2019_2097_MOESM2_ESM.docx (35 kb)
Supplementary material 2 (DOCX 34 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, College of MedicineSeoul National UniversitySeoulRepublic of Korea
  2. 2.Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, College of MedicineSeoul National UniversitySeoulSouth Korea
  3. 3.Department of Nuclear MedicineSeoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoulSouth Korea
  4. 4.Department of Biomedical StatisticsSeoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoulSouth Korea
  5. 5.Department of Neurology, Seoul National University Hospital, College of MedicineSeoul National UniversitySeoulSouth Korea

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