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Journal of Neural Transmission

, Volume 126, Issue 6, pp 789–793 | Cite as

Assessment of plasma creatine kinase as biomarker for levodopa-induced dyskinesia in Parkinson’s disease

  • Anna Delamarre
  • François Tison
  • Qin Li
  • Monique Galitzky
  • Olivier Rascol
  • Erwan Bezard
  • Wassilios G. MeissnerEmail author
Neurology and Preclinical Neurological Studies - Short communication

Abstract

We tested in a translational approach the usefulness of plasma creatine kinase (CK) as an objective biomarker for levodopa-induced dyskinesia (LID). Plasma CK levels were measured in five dyskinetic parkinsonian non-human primates (NHP) and in ten PD patients with LID who participated in a treatment trial with simvastatin. Plasma CK levels were increased in dyskinetic NHP and correlated with LID severity while they were not affected by LID severity in PD patients.

Keywords

Parkinson’s disease Levodopa-induced dyskinesia Biomarker Creatine kinase 

Notes

Acknowledgements

The Simvastatin trial was funded by a Michael J. Fox Foundation Clinical Intervention Award 2008.

Funding

The Simvastatin trial was funded by a M. J. Fox Foundation Clinical Intervention Award 2008.

Compliance with ethical standards

Conflict of interest

None of the authors has a conflict of interest in relation to the research covered in the article. Outside the present study (past 12 months), QL and MG have nothing to declare. AD declares a grant from the Fondation pour la recherche médicale (FDM201806005951). FT has received a travel grant from ORKYN and research grants from the French Health Ministry (PHRC). EB has an equity stake in Motac holding Ltd and receives consultancy payments from Motac Neuroscience Ltd. Current grant support includes Agence Nationale de la Recherche, China Science Fund, Michael J Fox Foundation for Parkinson Research, France Parkinson, Fondation de France, Medical Research Council, Innovative Medicines Initiative (H2020, IMPRIND), IDEX Bordeaux, COEN, MSA Coalition, Rotary Foundation, Nouvelle-Aquitaine Regional Council, and LABEX Brain. OR has received grants from Agence Nationale de la Recherche (ANR), CHU de Toulouse, France-Parkinson, INSERM-DHOS Recherche Clinique Translationnelle, MJFox Foundation, Programme Hospitalier de Recherche Clinique, European Commission (FP7, H2020) and has served as scientific consultant for AbbVie, Adamas, Acorda, Addex, AlzProtect, Apopharma, Astra Zeneca, Bial, Biogen, Britannia, Clevexel, Cynapsus, INC Research, Lundbeck, Merck, MundiPharma, Neuroderm, Novartis, Oxford Biomedica, Parexel, Pfizer, Prexton Therapeutics, Quintiles, Sanofi, Servier, Teva, UCB, XenoPort, Zambon. EB has an equity stake in Motac holding Ltd and receives consultancy payments from Motac Neuroscience Ltd. Current grant support includes Agence Nationale de la Recherche, China Science Fund, Michael J Fox Foundation for Parkinson Research, France Parkinson, Fondation de France, Medical Research Council, Innovative Medicines Initiative (H2020, IMPRIND), IDEX Bordeaux, COEN, MSA Coalition, Rotary Foundation, Nouvelle-Aquitaine Regional Council, and LABEX Brain. WGM has received fees for editorial activities with Springer Nature, honoraria for consultancy activities from Sanofi, Lundbeck and Affiris, teaching honoraria from UCB, honoraria from MDS, as well as research support from the Michael J Fox Foundation, the University Hospital Bordeaux, the French Health Ministry, the European Community, ANR, ARAMISE, PSP-France, MSA Coalition, LABEX Excellence Initiative.

Ethical approval

All animal experiments were performed in accordance with the European Union directive of September 22, 2010 (2010/63/EU) on the protection of animals used for scientific purposes in an AAALAC-accredited facility following acceptance of study design by the Institute of Lab Animal Science (Chinese Academy of Science, Beijing, China).

Written consent

Written consent of all subjects of the simvastatin trial was obtained prior to enrolment and following ethics approval (CPP Sud-Ouest et Outremer 3).

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Service de NeurologieHôpital Pellegrin, CHU de BordeauxBordeauxFrance
  2. 2.Institut des Maladies Neurodégénératives, Université de Bordeaux, UMR 5293Bordeaux CedexFrance
  3. 3.CNRS, Institut des Maladies Neurodégénératives, UMR 5293BordeauxFrance
  4. 4.Institute of Laboratory Animal SciencesChina Academy of Medical SciencesBeijingChina
  5. 5.Motac NeuroscienceManchesterUK
  6. 6.CIC ToulouseToulouseFrance
  7. 7.Départements de Pharmacologie Clinique et NeurosciencesINSERM CIC9302, CHU de ToulouseToulouseFrance
  8. 8.Service de Pharmacologie, Faculté de Médecine, CHU de ToulouseUniversité de ToulouseToulouseFrance
  9. 9.Department MedicineUniversity of OtagoChristchurchNew Zealand
  10. 10.New Zealand Brain Research InstituteChristchurchNew Zealand

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