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Journal of Neural Transmission

, Volume 126, Issue 3, pp 309–318 | Cite as

Longterm outcome of cognition, affective state, and quality of life following subthalamic deep brain stimulation in Parkinson’s disease

  • Doreen GruberEmail author
  • Lisa Calmbach
  • Andrea A. Kühn
  • Patricia Krause
  • Ute A. Kopp
  • Gerd-Helge Schneider
  • Andreas Kupsch
Neurology and Preclinical Neurological Studies - Original Article

Abstract

Normal cognition is an established selection criteria for subthalamic (STN) deep brain stimulation (DBS) in Parkinson’s disease (PD), while concern has been raised as to aggravated cognitive decline in PD patients following STN-DBS. The present longterm study investigates cognitive status in all patients (n = 104) suffering from PD, who were treated via continuous bilateral STN-DBS between 1997 and 2006 in a single institution. Preoperative neuropsychological results were available in 79/104 of the patients. Thirty-seven of these patients were additionally assessed after 6.3 ± 2.2 years (range 3.6–10.5 years) postsurgery via neuropsychological and motor test batteries, classifying cognitive conditions according to established criteria. At DBS-surgery patients, available for longterm follow-up (n = 37; mean age 67.6 ± 6.9 years, mean disease duration 11.3 ± 4.1 years), showed no (24.3%; 9/37) or mild preoperative cognitive impairment (MCI, 75.7%; 28/37). Postoperatively (mean disease duration: 17.1 ± 5.1 years), 19% of the patients (7/37) had no cognitive impairment, while 41% of the patients presented with either MCI or dementia (15/37, respectively). Preoperative MCI correlated with conversion to dementia by trend. Overall, STN-DBS-treated patients deteriorated by 1.6/140 points/year in the Mattis dementia rating scale. Disease duration, but not age, at DBS-surgery negatively correlated with postoperative cognitive decline and positively correlated with conversion to dementia. This observational, “real-life” study provides longterm results of cognitive decline in STN-DBS-treated patients with presurgical MCI possibly predicting the conversion to dementia. Although, the present data is lacking a control group of medically treated PD patients, comparison with other studies on cognition and PD do not support a disease-modifying effect of STN-DBS on cognitive domains.

Keywords

Deep brain stimulation Parkinson’s disease Cognition Quality of life 

Abbreviations

BAI

Beck Anxiety Inventory

BDI

Beck Depression Inventory

BPRS

Brief Psychiatric Rating Scale

BRMS

Bech-Rafaelsen-Mania Scale

DBS

Deep brain stimulation

LED

Levodopa equivalent dosage

MADRS

Montgomery and Asberg Depression Rating Scale

mMDRS

Modified Mattis Dementia Rating Scale

MDMQ

Multidimensional Mood State Questionnaire

OR

Odds ratio

PD

Parkinson’s disease

PD-D

Parkinson’s disease with dementia

PD-MCI

Parkinson’s disease with mild cognitive impairment

PD-NC

Parkinson’s disease with normal cognition

PDQ 39

Parkinson’s Disease Questionnaire

QoL

Quality of life

RBD

REM sleep behaviour disorder

RAVLT

Rey Auditory Verbal Learning Test

SF 36

36-item Short-Form Health Survey

SHAPS-D

Snaith–Hamilton-Pleasure-Scale

STN

Nucleus subthlamicus

TMT

Trail Making Test

UPDRSm

Unified Parkinson’s Disease Rating Scale, motor subscore

Notes

Acknowledgements

We thank our patients for their continued support of our work.

Funding

University Medicine Berlin, Charité.

Compliance with ethical standards

Conflict of interest

DG has received honoraria for speaking from Medtronic, outside the submitted work. AAK is a consultant to Boston Scientific and has received honoraria for speaking from Medtronic, Boston Scientific and Abbott, also grants from Medtronic, all outside the submitted work. GHS has received honoraria for speaking from Medtronic, and Boston Scientific, outside the submitted work. AK has received honoraria for speaking from Medtronic and Abbott, outside the submitted work. LC and UK declare that they have no conflicts of interest.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Doreen Gruber
    • 1
    • 2
    • 4
    Email author
  • Lisa Calmbach
    • 2
    • 4
  • Andrea A. Kühn
    • 2
  • Patricia Krause
    • 2
  • Ute A. Kopp
    • 2
  • Gerd-Helge Schneider
    • 3
  • Andreas Kupsch
    • 4
    • 5
  1. 1.Movement Disorders ClinicBeelitz-HeilstaettenGermany
  2. 2.Movement Disorders and Neuromodulation Unit, Department of NeurologyCharité University Medicine BerlinBerlinGermany
  3. 3.Department of NeurosurgeryCharité University Medicine BerlinBerlinGermany
  4. 4.Department of Neurology and Stereotactic NeurosurgeryOtto-von-Guericke-UniversityMagdeburgGermany
  5. 5.NEUROLOGY MOVES, Movement Disorder Center BerlinBerlinGermany

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