Journal of Neural Transmission

, Volume 126, Issue 4, pp 433–448 | Cite as

Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson’s disease

  • John P. M. FinbergEmail author
Neurology and Preclinical Neurological Studies - Review Article


MAO-B and COMT are both enzymes involved in dopamine breakdown and metabolism. Inhibitors of these enzymes are used in the treatment of Parkinson’s disease. This review article describes the scientific background to the localization and function of the enzymes, the physiological changes resulting from their inhibition, and the basic and clinical pharmacology of the various inhibitors and their role in treatment of Parkinson’s disease.


MAO-B COMT l-DOPA Dopamine synthesis Dyskinesia 


Compliance with ethical standards

Conflict of interest

The author was a developer of rasagiline and receives royalties from the sale of this drug. This financial connection with the pharmaceutical industry in no way affected his opinions in writing this article.


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© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neuroscience GroupRappaport Faculty of MedicineHaifaIsrael

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