Journal of Neural Transmission

, Volume 124, Issue 11, pp 1401–1405 | Cite as

CSF tapping also improves mental imagery of gait in normal pressure hydrocephalus

  • Bruno Marques
  • Magali Laidet
  • Stéphane Armand
  • Frédéric Assal
  • Gilles Allali
Neurology and Preclinical Neurological Studies - Short communication


This study aims to compare the changes of Timed Up and Go (TUG) and its imagined version (iTUG) after CSF tapping between patients with idiopathic normal pressure hydrocephalus (iNPH) and its mimics. TUG and iTUG were performed before and 24 h after CSF tapping in 117 patients (75.8 ± 6.9 years; 35% female) with suspicion of iNPH (68 iNPH and 49 mimics). Mental imagery of locomotion was modified after CSF tapping in iNPH patients, but not in the mimics.


Idiopathic normal pressure hydrocephalus Gait disorders Mental imagery Mimics CSF tapping 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


This study was supported by the Geneva University Hospitals (PRD 11-I-3 and PRD 12-2013-I); Gilles Allali was supported by the Baasch-Medicus Foundation.


  1. Allali G, Laidet M, Beauchet O, Herrmann FR, Assal F, Armand S (2013) Dual-task related gait changes after CSF tapping: a new way to identify idiopathic normal pressure hydrocephalus. J Neuroeng Rehabil 10:117. doi: 10.1186/1743-0003-10-117 CrossRefPubMedPubMedCentralGoogle Scholar
  2. Allali G, Annweiler C, Predovan D, Bherer L, Beauchet O (2016) Brain volume changes in gait control in patients with mild cognitive impairment compared to cognitively healthy individuals; GAIT study results. Exp Gerontol 76:72–79. doi: 10.1016/j.exger.2015.12.007 CrossRefPubMedGoogle Scholar
  3. Allali G, Laidet M, Armand S, Momjian S, Marques B, Saj A, Assal F (2017) A combined cognitive and gait quantification to identify normal pressure hydrocephalus from its mimics: the Geneva’s protocol. Clin Neurol Neurosurg 160:5–11. doi: 10.1016/j.clineuro.2017.06.001 CrossRefPubMedGoogle Scholar
  4. Aylward EH, Schwartz J, Machlin S, Pearlson G (1991) Bicaudate ratio as a measure of caudate volume on MR images. AJNR Am J Neuroradiol 12(6):1217–1222PubMedGoogle Scholar
  5. Beauchet O, Annweiler C, Assal F, Bridenbaugh S, Herrmann FR, Kressig RW, Allali G (2010) Imagined timed up and go test: a new tool to assess higher-level gait and balance disorders in older adults? J Neurol Sci 294(1–2):102–106. doi: 10.1016/j.jns.2010.03.021 CrossRefPubMedGoogle Scholar
  6. Beauchet O, Launay CP, Sejdic E, Allali G, Annweiler C (2014) Motor imagery of gait: a new way to detect mild cognitive impairment? J Neuroeng Rehabil 11:66. doi: 10.1186/1743-0003-11-66 CrossRefPubMedPubMedCentralGoogle Scholar
  7. Herman T, Giladi N, Hausdorff JM (2011) Properties of the ‘timed up and go’ test: more than meets the eye. Gerontology 57(3):203–210. doi: 10.1159/000314963 CrossRefPubMedGoogle Scholar
  8. Jeannerod M (1995) Mental imagery in the motor context. Neuropsychologia 33(11):1419–1432CrossRefPubMedGoogle Scholar
  9. Laidet M, Herrmann FR, Momjian S, Assal F, Allali G (2015) Improvement in executive subfunctions following cerebrospinal fluid tap test identifies idiopathic normal pressure hydrocephalus from its mimics. Eur J Neurol 22(12):1533–1539. doi: 10.1111/ene.12779 CrossRefPubMedGoogle Scholar
  10. Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM (2005) Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57(3 Suppl):S4–16 (discussion ii–v) PubMedGoogle Scholar
  11. Schniepp R, Trabold R, Romagna A, Akrami F, Hesselbarth K, Wuehr M, Peraud A, Brandt T, Dieterich M, Jahn K (2017) Walking assessment after lumbar puncture in normal-pressure hydrocephalus: a delayed improvement over 3 days. J Neurosurg 126(1):148–157. doi: 10.3171/2015.12.JNS151663 CrossRefPubMedGoogle Scholar
  12. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjogren M, Wallin A, Ader H, Leys D, Pantoni L, Pasquier F, Erkinjuntti T, Scheltens P, European Task Force on Age-Related White Matter C (2001) A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke J Cereb Circ 32(6):1318–1322CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria 2017

Authors and Affiliations

  1. 1.Faculty of MedicineUniversity of GenevaGenevaSwitzerland
  2. 2.Division of Neurology, Department of Clinical NeurosciencesGeneva University HospitalsGenevaSwitzerland
  3. 3.Willy Taillard Laboratory of KinesiologyGeneva University HospitalsGenevaSwitzerland
  4. 4.University of GenevaGenevaSwitzerland
  5. 5.Division of Cognitive and Motor Aging, Department of Neurology, Albert Einstein College of MedicineYeshiva UniversityBronxUSA
  6. 6.Department of NeurologyGeneva University HospitalsGenevaSwitzerland

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