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Journal of Neural Transmission

, Volume 124, Issue 3, pp 353–360 | Cite as

Relationship between the plasma levels of neurodegenerative proteins and motor subtypes of Parkinson’s disease

  • Jian Ding
  • Jiejin Zhang
  • Xixi Wang
  • Li Zhang
  • Siming Jiang
  • Yongsheng Yuan
  • Junyi Li
  • Lin Zhu
  • Kezhong ZhangEmail author
Neurology and Preclinical Neurological Studies - Original Article

Abstract

The aim of our study is to examine the plasma levels of the four kinds of neurodegenerative proteins in plasma: α-syn, T-tau, P-tau181, and Aβ-42 in Parkinson’s disease (PD) and to evaluate the relationship between their plasma levels and PD motor subtypes. 84 patients with PD were enrolled in our study, and finally, 73 of them were classified into the tremor-dominant subtype (TD) and the postural instability gait difficulty subtype (PIGD). Their motor performance was evaluated by a series of clinical assessments: Freezing of Gait Questionnaire (FOGQ), Timed Up and Go (TUGs), Tinetti balance, and Tinetti gait. Plasma levels of these proteins were measured by enzyme-linked immunosorbent assay (ELISA). The plasma level of α-syn was significantly higher in PD patients when compared to controls (p = 0.004), and significantly higher in the PIGD group when compared to the TD group (p = 0.03). While the plasma level of Aβ-42 was significantly lower in PD patients than in controls (p = 0.002), and significantly lower in the PIGD group than in the TD group (p = 0.05). In PD patients, the plasma level of α-syn (r = −0.355, p < 0.001) was significantly related to the severity of Tenitti Gait score, even after performing multiple linear regression (p = 0.002). While the plasma level of Aβ-42 (r = −0.261, p < 0.05) was significantly associated with the severity of PIGD score and remained correlate when performed multiple linear regression (p = 0.005). The patients with PIGD subtype are characterized with a lower level of plasma Aβ-42 and a higher plasma level of α-syn, which may be used as biomarkers for diagnosis and progression of the subtypes of PD.

Keywords

Parkinson’s disease Postural instability gait difficulty subtype Tremor-dominant subtype Neurodegenerative proteins 

Notes

Acknowledgements

This work was supported by the Natural science foundation of Jiangsu Province (No. BK20141494), the Jiangsu Provincial Personnel Department “the Great of Six Talented Man Peak” Project (No. 2014-WSN-013), the University Natural Science Research Project in Jiangsu Province (No. 13KJB32009), the Opening Project of Jiangsu Key Laboratory of Neurodegeneration (No. SJ11KF01),and Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and Science and Technology Project of Jiangsu Bureau of Traditional Chinese Medicine (No. YB2015163).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Jian Ding
    • 1
  • Jiejin Zhang
    • 1
  • Xixi Wang
    • 1
  • Li Zhang
    • 1
  • Siming Jiang
    • 1
  • Yongsheng Yuan
    • 1
  • Junyi Li
    • 1
  • Lin Zhu
    • 1
  • Kezhong Zhang
    • 1
    Email author
  1. 1.Department of NeurologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

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