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Journal of Neural Transmission

, Volume 123, Issue 12, pp 1387–1393 | Cite as

Theta burst stimulation over premotor cortex in Parkinson’s disease: an explorative study on manual dexterity

  • Tim Vanbellingen
  • Manuela Wapp
  • Katharina Stegmayer
  • Manuel Bertschi
  • Eugenio Abela
  • Stefanie Kübel
  • Thomas Nyffeler
  • René Müri
  • Sebastian Walther
  • Tobias Nef
  • Mark Hallett
  • Stephan Bohlhalter
Neurology and Preclinical Neurological Studies - Original Article

Abstract

Dorsal pre-motor cortex (PMd) is thought to play a role in fine motor control. The aim of the present study was to investigate whether inhibitory or excitatory stimulation of PMd would have an impact on manual dexterity in Parkinson’s disease (PD). Fifteen patients with PD participated in this study. High resolution structural MRI was used for neuro-navigated TBS. Participants were targeted with one train of TBS in three experimental sessions: sham stimulation over vertex, continuous TBS (cTBS) over PMd and intermittent TBS (iTBS) over PMd, respectively. Dexterity was measured by a coin rotation task (CRT), which is a valid measure to detect limb kinetic apraxia (LKA). Neither cTBS or iTBS significantly interfered with CRT. Post hoc sub-analysis in a group of PD patients (n = 5) with stronger baseline impairment, indicating LKA, revealed further deterioration of dexterous performance for the cTBS condition (p = 0.04). This sham controlled pilot study demonstrates that TBS over PMd does not significantly interfere with dexterity in PD. However, patients with dexterous impairment qualifying for LKA may be more susceptible to TBS.

Keywords

Manual dexterity Premotor cortex Limb kinetic apraxia Parkinson’s disease Coin rotation 

Notes

Acknowledgments

We are grateful for the skilled editing by Prof. Dr. Einar Wilder-Smith. This study was supported by the Swiss National Science Foundation, Grant No. 320030_129668/1.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Tim Vanbellingen
    • 1
    • 2
    • 3
  • Manuela Wapp
    • 4
  • Katharina Stegmayer
    • 5
  • Manuel Bertschi
    • 2
  • Eugenio Abela
    • 4
  • Stefanie Kübel
    • 1
  • Thomas Nyffeler
    • 1
    • 2
    • 3
  • René Müri
    • 2
    • 3
  • Sebastian Walther
    • 5
  • Tobias Nef
    • 3
    • 6
  • Mark Hallett
    • 7
  • Stephan Bohlhalter
    • 1
    • 2
  1. 1.Neurology and Neurorehabilitation CenterLuzerner KantonsspitalLucerneSwitzerland
  2. 2.Perception and Eye Movement Laboratory, Departments of Neurology and Clinical ResearchInselspital, University Hospital BernBernSwitzerland
  3. 3.ARTORG Center for Biomedical Engineering ResearchUniversity of BernBernSwitzerland
  4. 4.Support Center for Advanced Neuroimaging (SCAN), Institute of Diagnostic and Interventional NeuroradiologyInselspital, University Hospital BernBernSwitzerland
  5. 5.University Hospital of PsychiatryBernSwitzerland
  6. 6.Gerontechnology and Rehabilitation GroupUniversity of BernBernSwitzerland
  7. 7.Human Motor Control Section, National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaUSA

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