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Journal of Neural Transmission

, Volume 123, Issue 9, pp 1037–1052 | Cite as

The transgenerational transmission of childhood adversity: behavioral, cellular, and epigenetic correlates

  • Nicole Gröger
  • Emmanuel Matas
  • Tomasz Gos
  • Alexandra Lesse
  • Gerd Poeggel
  • Katharina Braun
  • Jörg Bock
Psychiatry and Preclinical Psychiatric Studies - Review Article

Abstract

The view that the functional maturation of the brain is the result of an environmentally driven adaptation of genetically preprogrammed neuronal networks is an important current concept in developmental neuroscience and psychology. This hypothesis proposes that early traumatic experiences or early life stress (ELS) as a negative environmental experience provide a major risk factor for the development of dysfunctional brain circuits and as a consequence for the emergence of behavioral dysfunctions and mental disorders in later life periods. This view is supported by an increasing number of clinical as well as experimental animal studies revealing that early life traumas can induce functional ‘scars’ in the brain, especially in brain circuits, which are essential for emotional control, learning, and memory functions. Such gene × environment interactions are modulated by specific epigenetic mechanisms, which are suggested to be the key factors of transgenerational epigenetic inheritance. Indeed, there is increasing evidence for inter- and transgenerational cycles of environmentally driven neuronal and behavioral adaptations mediated by epigenetic mechanisms. Finally, recent concepts postulate that, dependent on type, time point, and duration of ELS exposure, also positive functional adaptations may occur in the relevant brain pathways, leading to better stress coping and resilience against adversities later in life.

Keywords

Early life stress Psychopathology Resilience Epigenetics Sex differences 

Notes

Acknowledgments

This work was supported by Grants from the Bundesministerium für Bildung und Forschung (BMBF; UBICA, 01KR1207D to JB and TRANSGEN 01KR1304B to KB) and a grant from the German–Israeli Foundation for Scientific Research and Development (GIF) to KB.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Nicole Gröger
    • 1
  • Emmanuel Matas
    • 1
  • Tomasz Gos
    • 2
  • Alexandra Lesse
    • 1
  • Gerd Poeggel
    • 3
  • Katharina Braun
    • 1
    • 5
  • Jörg Bock
    • 4
    • 5
  1. 1.Department of Zoology/Developmental Neurobiology, Institute of BiologyOtto von Guericke University MagdeburgMagdeburgGermany
  2. 2.Department of Forensic MedicineMedical University of GdańskGdańskPoland
  3. 3.Institute for Biology, Human BiologyUniversity of LeipzigLeipzigGermany
  4. 4.PG “Epigenetics and Structural Plasticity”, Institute of BiologyOtto von Guericke University MagdeburgMagdeburgGermany
  5. 5.Center for Behavioral Brain SciencesMagdeburgGermany

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