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Journal of Neural Transmission

, Volume 123, Issue 4, pp 371–377 | Cite as

Serum uric acid is associated with apathy in early, drug-naïve Parkinson’s disease

  • Marina Picillo
  • Gabriella Santangelo
  • Marcello Moccia
  • Roberto Erro
  • Marianna Amboni
  • Elio Prestipino
  • Katia Longo
  • Carmine Vitale
  • Emanuele Spina
  • Giuseppe Orefice
  • Paolo Barone
  • Maria Teresa Pellecchia
Neurology and Preclinical Neurological Studies - Original Article

Abstract

Both low serum uric acid (UA) levels and apathy are considered biomarkers of cognitive decline and dementia in Parkinson’s disease (PD). There is an urgent need to combine different biomarkers to predict disease course in PD. Data on the relationship between serum UA levels and apathy in PD are lacking. The aim of this study is to evaluate the relationship between serum UA levels and pure apathy in early, drug-naïve PD patients. Forty-nine early, drug-naïve PD patients were enrolled and stratified into two groups using the median serum UA levels at diagnosis (Group 1 serum UA ≤ 4.8 mg/dl; Group 2 serum UA > 4.8 mg/dl). The cohort was followed for the first 2 years of disease. Apathy was evaluated with the Apathy Evaluation Scale (AES). Patients with lower serum UA levels presented significant higher AES score compared to patients with higher serum UA levels. Regression analysis showed that baseline serum UA levels were significant determinants of AES scores at both baseline and 2-year follow up, irrespective of gender, age, attention/executive functions and dopamine replacement therapy when applicable. This is the first study showing a link between serum UA levels and apathy in non-demented, non-depressed, early, drug-naïve PD, being lower serum UA levels associated with greater apathy. Further follow up of our patients and replication of this observation in independent cohorts are needed to establish if this combination of biomarkers may help in characterizing a subgroup of PD patients at diagnosis.

Keywords

Parkinson’s disease Early Parkinson Apathy Acid uric Urate Cognition Biomarker 

Notes

Compliance with ethical standards

Funding statement

This work was supported by the University of Salerno, FARB 2012 (ORSA127397).

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Financial disclosures

Dr Marina Picillo has received salary from the University of Salerno, University Health Network, Toronto, Canada. She also received grant from the Michael J. Fox Foundation. Dr Marcello Moccia, Prof Giuseppe Orefice have received salary from the Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy. Dr Marianna Amboni has received honoraria for symposia from Boehringer Ingelheim, Lundbeck, Novartis. She has received salary from IDC “Hermitage-Capodimonte”, Naples, Italy. Dr Katia Longo has received salary from IDC Hermitage-Capodimonte, Naples, Italy. Dr Carmine Vitale has received honoraria for symposia from Boehringer Ingelheim, Lundbeck, Novartis, Schwarz Pharma/UCB. He has received salary from IDC Hermitage-Capodimonte and the University of Naples “Parthenope”, Italy. Dr Gabriella Santangelo has received salary from Second University of Naples. Dr Maria Teresa Pellecchia has received honoraria for symposia from Boehringer Ingelheim, Lundbeck, Novartis. She has received salary from the University of Salerno, Italy. Prof Paolo Barone has received honoraria as a Consultant and Advisory Board Memberships for Novartis, Schwarz Pharma/UCB, Merck-Serono, Eisai, Solvay, General Electric and Lundbeck. He has received research support from Boehringer Ingelheim, Novartis, Schwarz Pharma/UCB, Merck-Serono, Solvay, and Lundbeck. He has received salary from the University of Salerno, Italy.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Marina Picillo
    • 1
  • Gabriella Santangelo
    • 2
    • 3
  • Marcello Moccia
    • 4
  • Roberto Erro
    • 5
  • Marianna Amboni
    • 1
    • 3
  • Elio Prestipino
    • 4
  • Katia Longo
    • 3
  • Carmine Vitale
    • 3
    • 6
  • Emanuele Spina
    • 4
  • Giuseppe Orefice
    • 4
  • Paolo Barone
    • 1
  • Maria Teresa Pellecchia
    • 1
  1. 1.Center for Neurodegenerative Diseases (CEMAND), Department of Medicine and Surgery, Neuroscience SectionUniversity of SalernoFiscianoItaly
  2. 2.Neuropsychology Laboratory, Department of PsychologySecond University of NaplesCasertaItaly
  3. 3.IDC Hermitage-CapodimonteNaplesItaly
  4. 4.Department of Neuroscience, Reproductive Science and OdontostomatologyFederico II UniversityNaplesItaly
  5. 5.Department of Neurological and Movement SciencesUniversity of VeronaVeronaItaly
  6. 6.University of Naples ParthenopeNaplesItaly

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