Journal of Neural Transmission

, Volume 124, Supplement 1, pp 127–138 | Cite as

The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update

  • Alexander DueckEmail author
  • Christoph Berger
  • Katharina Wunsch
  • Johannes Thome
  • Stefan Cohrs
  • Olaf Reis
  • Frank Haessler
Psychiatry and Preclinical Psychiatric Studies - Review Article


A more recent branch of research describes the importance of sleep problems in the development and treatment of mental disorders in children and adolescents, such as attention-deficit hyperactivity disorder (ADHD) and mood disorders (MD). Research about clock genes has continued since 2012 with a focus on metabolic processes within all parts of the mammalian body, but particularly within different cerebral regions. Research has focused on complex regulatory circuits involving clock genes themselves and their influence on circadian rhythms of diverse body functions. Current publications on basic research in human and animal models indicate directions for the treatment of mental disorders targeting circadian rhythms and mechanisms. The most significant lines of research are described in this paper.


Child and adolescent psychiatry ADHD MDD Animal model Circadian rhythm Sleep disorder 


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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Alexander Dueck
    • 1
    Email author
  • Christoph Berger
    • 1
  • Katharina Wunsch
    • 1
  • Johannes Thome
    • 2
  • Stefan Cohrs
    • 2
  • Olaf Reis
    • 1
  • Frank Haessler
    • 1
  1. 1.Clinic of Child- and Adolescence Psychiatry, Neurology, Psychosomatics and PsychotherapyUniversity of RostockRostockGermany
  2. 2.Clinic of Psychiatry and PsychotherapyUniversity of RostockRostockGermany

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