Elevated fecal calprotectin in patients with Alzheimer’s dementia indicates leaky gut
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Fecal concentrations of calprotectin were examined in 22 patients with Alzheimer’s disease (AD) and compared with serum concentrations of aromatic amino acids. Calprotectin concentrations were mean ± SEM 140 ± 31.9 mg/kg, 16 patients (73 %) presented with concentrations outside normal (>50 mg/kg). Concentrations correlated inversely with serum levels of tryptophan, tyrosine and phenylalanine (all p < 0.05). Increased concentrations of fecal calprotectin indicate a disturbed intestinal barrier function in AD patients which could be of relevance for the lowering of essential aromatic amino acids concentrations in the blood.
KeywordsAlzheimer disease Calprotectin Leaky gut Phenylalanine Tryptophan Tyrosine
The authors thank Mr. Simon Geisler and Mr. Thomas Nuener for excellent technical assistance.
Conflict of interest
- Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V (2012) Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 37:1885–1895CrossRefPubMedGoogle Scholar