Journal of Neural Transmission

, Volume 122, Issue 2, pp 253–256 | Cite as

Amplitude-oriented exercise in Parkinson’s disease: a randomized study comparing LSVT-BIG and a short training protocol

  • Georg Ebersbach
  • Ute Grust
  • Almut Ebersbach
  • Brigitte Wegner
  • Florin Gandor
  • Andrea A. Kühn
Neurology and Preclinical Neurological Studies - Short communication


LSVT-BIG is an exercise for patients with Parkinson’s disease (PD) comprising of 16 1-h sessions within 4 weeks. LSVT-BIG was compared with a 2-week short protocol (AOT-SP) consisting of 10 sessions with identical exercises in 42 patients with PD. UPDRS-III-score was reduced by −6.6 in LSVT-BIG and −5.7 in AOT-SP at follow-up after 16 weeks (p < 0.001). Measures of motor performance were equally improved by LSVT-BIG and AOT-SP but high-intensity LSVT-BIG was more effective to obtain patient-perceived benefit.


Parkinson’s disease LSVT-BIG Exercise Physiotherapy 



We thank Deutsche Parkinson Gesellschaft for financial and organizational support. We also thank Heike Unger and physiotherapists in Beelitz-Heilstätten for skillfully exercising participants. This work was supported by an unrestricted Grant from Deutsche Parkinson Gesellschaft.

Conflict of interest

The authors have no financial disclosures to make and no conflict of interest to report with respect to the research reported in this manuscript.

Supplementary material

702_2014_1245_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 13 kb)


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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Georg Ebersbach
    • 1
  • Ute Grust
    • 1
  • Almut Ebersbach
    • 1
  • Brigitte Wegner
    • 2
  • Florin Gandor
    • 1
  • Andrea A. Kühn
    • 3
  1. 1.Fachkrankenhaus für Bewegungsstörungen/ParkinsonBeelitz-HeilstättenGermany
  2. 2.Institute of Medical Biometrics and Clinical EpidemiologyCharité University MedicineBerlinGermany
  3. 3.Department of NeurologyCharité University Medicine BerlinBerlinGermany

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