Journal of Neural Transmission

, Volume 121, Issue 11, pp 1367–1376 | Cite as

Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease

  • Yin Ding
  • Brian Spund
  • Sofya Glazman
  • Eric M. Shrier
  • Shahnaz Miri
  • Ivan Selesnick
  • Ivan Bodis-Wollner
Neurology and Preclinical Neurological Studies - Original Article


Spectral-domain Optical coherence tomography (OCT) has shown remarkable utility in the study of retinal disease and has helped to characterize the fovea in Parkinson disease (PD) patients. We developed a detailed mathematical model based on raw OCT data to allow differentiation of foveae of PD patients from healthy controls. Of the various models we tested, a difference of a Gaussian and a polynomial was found to have “the best fit”. Decision was based on mathematical evaluation of the fit of the model to the data of 45 control eyes versus 50 PD eyes. We compared the model parameters in the two groups using receiver-operating characteristics (ROC). A single parameter discriminated 70 % of PD eyes from controls, while using seven of the eight parameters of the model allowed 76 % to be discriminated. The future clinical utility of mathematical modeling in study of diffuse neurodegenerative conditions that also affect the fovea is discussed.


Fovea Retinal imaging Optical coherence tomography (OCT) Parkinson disease (PD) Mathematical modeling 


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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Yin Ding
    • 1
  • Brian Spund
    • 2
  • Sofya Glazman
    • 3
  • Eric M. Shrier
    • 4
    • 5
  • Shahnaz Miri
    • 3
  • Ivan Selesnick
    • 1
    • 6
  • Ivan Bodis-Wollner
    • 3
    • 4
    • 5
    • 6
  1. 1.Department of Electrical and Computer EngineeringPolytechnic Institute of New York UniversityBrooklynUSA
  2. 2.North Shore University HospitalManhassetUSA
  3. 3.Department of NeurologySUNY Downstate Medical CenterBrooklynUSA
  4. 4.Department of OphthalmologySUNY Downstate Medical CenterBrooklynUSA
  5. 5.SUNY Eye InstituteAlbanyNY
  6. 6.The School of Graduate StudiesSUNY Downstate Medical CenterBrooklynUSA

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