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Journal of Neural Transmission

, Volume 121, Issue 4, pp 367–369 | Cite as

Tardive dystonic syndrome induced by the calcium-channel blocker amlodipine

  • Dirk Dressler
Neurology and Preclinical Neurological Studies - Short communication

Abstract

Identification of drug exposure as a cause for dystonia is important since cessation of the causative agent offers a chance for remission. We describe two patients with a cranial, cervical, pharyngo-laryngeal and axial dystonia, akathisia, breathing dysrhythmias together with depression and anxiety. Both patients were started on the calcium channel blocker (CCB) amlodipine 1 month before symptom onset. They symptoms were non-acute and due to CCBs well-known D2 antagonism; hence they were classified as a tardive dystonic syndrome. Parkinsonism and depression have been described especially for the CCB flunarizine and cinnarizine. Tardive dystonia under CCB has rarely been reported. CCB exposure should be investigated in all dystonias with cranial, cervical, pharyngo-laryngeal and axial manifestations, especially when additional akathisia, Parkinsonism and depression are present. When CCB induction is suspected, CCB cessation may offer a chance for spontaneous remission. Whether CCB exposure can deteriorate, idiopathic dystonia is unclear. Therefore, CCB should best be avoided in patients with dystonia.

Keywords

Tardive dystonia Calcium channel blocker Amlodipine Breathing dysrhythmia Akathisia Depression Anxiety Dopamine blockade 

Notes

Conflict of interest

DD received honoraria for consultations from Allergan, Eisai/Solstice, Ipsen, Merz and Syntaxin. He is a shareholder in Allergan. He holds patents in botulinum toxin research.

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  1. 1.Movement Disorders Section, Department of NeurologyHannover Medical SchoolHannoverGermany

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