Levodopa inhibits habit-learning in Parkinson’s disease
- First Online:
Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson’s disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.
KeywordsParkinson’s disease Habit-learning Levodopa Cognition
- Jahanshahi M, Wilkinson L, Gahir H, Dharmarinda A, Lagnado DA (2010) Medication impairs probabilistic classification learning in Parkinson’s disease. Neuropsychologia 48(4):1096–1103. doi:S0028-3932(09)00486-210.1016/j.neuropsychologia.2009.12.010 PubMedCrossRefGoogle Scholar
- Lezak M (1995) Neuropsychological Assessment. Oxford University Press, New YorkGoogle Scholar