Journal of Neural Transmission

, Volume 120, Issue 4, pp 571–576 | Cite as

In vivo neurochemical imaging of olfactory dysfunction in Parkinson’s disease

  • Nicolaas I. Bohnen
  • Martijn L. T. M. Müller
Neurology and Preclinical Neurological Studies - Original Article

Abstract

Olfactory dysfunction is common in Parkinson’s disease (PD) and has been attributed to early deposition of α-synuclein pathology in olfactory areas. The pathophysiology of olfactory dysfunction in PD, however, remains poorly understood. Changes in odor identification suggest in part impairment in odor memory, possibly due to hippocampal dysfunction. Olfactory dysfunction occurs also in Alzheimer’s disease (AD) and increases with severity of dementia. Cholinergic degeneration is not only a feature of AD but can also occur in PD, at least in a subset of patients with cognitive changes. We reported previously that impaired odor identification in early PD is more closely correlated with hippocampal dopaminergic than nigrostriatal dopaminergic denervation. Results of our multi-tracer PET studies show that odor identification deficits in PD are best predicted by cholinergic denervation and to a lesser extent by dopaminergic denervation. These results suggest that olfactory dysfunction in PD may have multiple components including hippocampal dysfunction secondary to cholinergic and dopaminergic denervations. Olfactory dysfunction in PD may be the most marked in subjects at risk of incipient dementia, and may reflect the transition of PD toward a stage with more heterogeneous multi-system neurodegenerations. Our preliminary imaging data do not support a significant contribution of amyloidopathy or serotoninergic denervation to abnormal olfactory functions in PD, at least in the absence of dementia. We outline how progressive changes in olfaction may be used as a biomarker of cholinergic denervation and cognitive decline in PD patients. We will discuss also the utility of olfactory testing as an early screening test for neurodegeneration.

Keywords

Acetylcholine Cognitive Dopamine Parkinson’s disease Olfaction Positron emission tomography 

Abbreviations

β-Amyloid

AChE

Acetylcholinesterase

AD

Alzheimer’s disease

DAT

Dopamine transporter

PD

Parkinson’s disease

PET

Positron emission tomography

SERT

Serotonin transporter

SPECT

Single photon computed emission tomography

UPSIT

University of Pennsylvania smell identification test

VMAT2

Vesicular monoamine transporter type 2

VTA

Ventral tegmental area

Notes

Acknowledgments

This work was supported by the Department of Veterans Affairs (I01 RX000317); the Michael J. Fox Foundation; and the National Institutes of Health (grant numbers P01 NS019608, NS015655 and RO1 NS070856).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

All subjects in our studies gave their informed consent prior to their inclusion in the studies, which have been approved by the ethic committees in accordance with the Declaration of Helsinki.

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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  • Nicolaas I. Bohnen
    • 1
    • 2
    • 3
    • 4
  • Martijn L. T. M. Müller
    • 1
  1. 1.Department of RadiologyUniversity of MichiganAnn ArborUSA
  2. 2.Department of NeurologyUniversity of MichiganAnn ArborUSA
  3. 3.Neurology Service and GRECCDepartment of Veterans AffairsAnn ArborUSA
  4. 4.Functional Neuroimaging, Cognitive and Mobility Laboratory, Departments of Radiology and NeurologyUniversity of MichiganAnn ArborUSA

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