Effects of dopaminergic and subthalamic stimulation on musical performance
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Although subthalamic-deep brain stimulation (STN-DBS) is an efficient treatment for Parkinson’s disease (PD), its effects on fine motor functions are not clear. We present the case of a professional violinist with PD treated with STN-DBS. DBS improved musical articulation, intonation and emotional expression and worsened timing relative to a timekeeper (metronome). The same effects were found for dopaminergic treatment. These results suggest that STN-DBS, mimicking the effects of dopaminergic stimulation, improves fine-tuned motor behaviour whilst impairing timing precision.
KeywordsParkinson’s disease Subthalamic nucleus Deep brain stimulation Dopamine Motor control Musical performance
This work was supported in part by an EBRAMUS grant to FTV (ITN MC FP7, GA 238157). We thank Dr. André Lee for helpful comments and discussions concerning the musical evaluation paradigm and Patricia Doucelance for help with the musical recordings.
Conflict of interest
The authors declare that they have no conflict of interest.
- Fahn S, Elton RL (1987) Unified Parkinson’s disease rating scale. In: Fahn S, Marsden CD, Calne DB, Goldstein M (eds) Recent developments in Parkinson’s disease. Macmillan, Florham Park, pp 153–163Google Scholar