Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study
- 754 Downloads
There is increasing evidence for the relationship between circadian rhythm disturbance and cognitive decline in the older adult. This study measured circadian activity rhythms in a small group of healthy community-dwelling older adults (n = 26). Each participant completed a battery of neuropsychological tests and completed sleep diaries and 6 days of actigraphy. Ten participants were identified as having very early signs of cognitive decline as indicated by their performance on the memory tests. Results showed minimal differences on the sleep/activity and circadian parameters across the two groups (declined vs. intact), although there was a significant difference in the acrophase between the declined and intact groups. These findings, although exploratory, suggest that very subtle changes in circadian rhythm may be detected in older adults showing pre-clinical changes in cognitive performance.
KeywordsSleep–wake Circadian Actigraphy Older adults Cognition
We acknowledge support from the Trinity College Dublin Arts and Social Sciences Benefaction Fund.
- Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Ensrud KE, Stefanick ML, Laffan A, Stone KL, Osteoporotic Fractures in Men Study Group (2011) Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc 59:2217–2225. doi: 10.1111/j.1532-5415.2011.03731 PubMedCrossRefGoogle Scholar
- Golden CJ, Freshwater SM (2002) Stroop colour and word test: revised examiner’s manual. Stoelting, Wood DaleGoogle Scholar
- Grundman M, Petersen RC, Ferris SH, Thomas RG, Aisen PS, Bennett DA, Foster NL, Jack CR Jr, Galasko DR, Doody R, Kaye J, Sano M, Mohs R, Gauthier S, Kim HT, Jin S, Schultz AN, Schafer K, Mulnard R, van Dyck CH, Mintzer J, Zamrini EY, Cahn-Weiner D, Thal LJ, Alzheimer’s Disease Cooperative Study (2004) Mild cognitive impairment can be distinguished from Alzheimer’s disease and normal ageing for clinical trials. Arch Neurol 61:59–66PubMedCrossRefGoogle Scholar
- Hogan MJ, Kenney JPM, Roche RAP, Keane M, Moore JL, Kaiser J (2012) Behavioural and electrophysiological effects of visual paired associate context manipulations during encoding and recognition in younger adults, older adults and older cognitively declined adults. Exp Brain Res 216:241–250CrossRefGoogle Scholar
- Horne JA, Ostberg O (1976) A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Intl J Chronbiol 4:97–110Google Scholar
- Kuhlmei A, Walther B, Becker T, Muller U, Nikolaus T (2011) Actigraphic daytime activity is reduced in patients with cognitive impairment and apathy. Eur Psychiatry (E-Pub June 2011)Google Scholar
- Nelson HE, Willison J (1991) National Adult Reading Test (NART): test manual, 2nd edn. NFER Nelson, WindsorGoogle Scholar
- Tranah GJ, Blackwell T, Stone KL, Ancoli-Israel S, Paudel ML, Ensrud KE, Cauley JA, Redline S, Hillier TA, Cummings SR, Yaffe K, SOF Research Group (2011) Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol 70(722):732Google Scholar