Journal of Neural Transmission

, Volume 119, Issue 7, pp 843–850

Longitudinal plasma amyloid beta as a biomarker of Alzheimer’s disease

  • Robert A. Rissman
  • John Q. Trojanowski
  • Leslie M. Shaw
  • Paul S. Aisen
Dementias - Review article

DOI: 10.1007/s00702-012-0772-4

Cite this article as:
Rissman, R.A., Trojanowski, J.Q., Shaw, L.M. et al. J Neural Transm (2012) 119: 843. doi:10.1007/s00702-012-0772-4

Abstract

Alzheimer’s disease (AD) affects more than twenty-five million people worldwide and is the most common form of dementia. Symptomatic treatments have been developed, but effective intervention to alter disease progression is needed. Targets have been identified for disease-modifying drugs, but the results of clinical trials have been disappointing. Peripheral biomarkers of disease state may improve clinical trial design and analysis, increasing the likelihood of successful drug development. Amyloid-related measures, presumably reflecting principal pathology of AD, are among the leading cerebrospinal fluid and neuroimaging biomarkers, and measurement of plasma levels of amyloid peptides has been the focus of much investigation. In this review, we discuss recent data on plasma β-amyloid (Aβ) and examine the issues that have arisen in establishing it as a reliable biomarker of AD.

Keywords

Alzheimer’s disease Protein biomarker Plasma amyloid 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Robert A. Rissman
    • 1
  • John Q. Trojanowski
    • 2
  • Leslie M. Shaw
    • 2
  • Paul S. Aisen
    • 1
  1. 1.Alzheimer’s Disease Cooperative Study, Department of NeurosciencesUCSD School of MedicineLa JollaUSA
  2. 2.Department of Pathology and Laboratory Medicine, Institute on AgingCenter for Neurodegenerative Disease Research, University of Pennsylvania School of MedicinePhiladelphiaUSA

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