Journal of Neural Transmission

, Volume 118, Issue 12, pp 1659–1660 | Cite as

Mechanisms underlying and medical management of l-Dopa-associated motor complications

  • Manfred Gerlach
  • Peter Riederer
  • Dieter Scheller

Motor complications, particularly motor fluctuations such as wearing-off, on–off phenomena, and several different types of dyskinesia such as peak-dose, diphasic, wearing-off, chorea, dystonia and athetosis (collectively called dyskinesia) seem to be an inevitable consequence of l-Dopa (l-3,4-dihydroxyphenylalanine, levodopa) therapy of patients suffering from Parkinson’s Disease (Jankovic 2005; Müller and Russ 2006). However, not all patients develop dyskinesia even after long periods of treatment suggesting that specific deteriorations or adaptations occur in one group of patients but not in the other. The present understanding of the underlying mechanisms of those differences is far from being known. The stage of the illness (degree of dopaminergic degeneration and loss of nigro-striatal projections) as well as the dose and frequency of l-Dopa treatment have been considered as essential contributors to the induction and expression of the involuntary movements. Age of the patients...


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Manfred Gerlach
    • 1
  • Peter Riederer
    • 2
  • Dieter Scheller
    • 3
  1. 1.Laboratory for Clinical Neurobiology, Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyUniversity of WürzburgWürzburgGermany
  2. 2.Laboratory for Clinical Neurochemistry, Department of Psychiatry, Psychosomatics and Psychotherapy, National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases ResearchUniversity of WürzburgWürzburgGermany
  3. 3.Department Pharmacology of Parkinson’s Disease and Movement DisordersCNS Research UCB Pharma S.ABraine l’AlleudBelgium

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