Journal of Neural Transmission

, Volume 118, Issue 11, pp 1547–1557

Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats

  • Romaiana Picada Pereira
  • Roselei Fachinetto
  • Alessandro de Souza Prestes
  • Caroline Wagner
  • Jéssie Haigert Sudati
  • Aline Augusti Boligon
  • Margareth Linde Athayde
  • Vera Maria Morsch
  • João Batista Teixeira Rocha
Basic Neurosciences, Genetics and Immunology - Original Article


Oral movements are associated with important neuropathologies as Parkinson’s disease and tardive dyskinesia. However, until this time, there has been no known efficacious treatment, without side effects, for these disorders. Thus, the aim of the present study was to investigate the possible preventive effects of V. officinalis, a phytotherapic that has GABAergic and antioxidant properties, in vacuous chewing movements (VCMs) induced by reserpine in rats. Adult male rats were treated with reserpine (1 mg/kg, s.c.) and/or with V. officinalis (in the drinking water, starting 15 days before the administration of the reserpine). VCMs, locomotor activity and oxidative stress measurements were evaluated. Furthermore, we carried out the identification of valeric acid and gallic acid by HPLC in the V. officinalis tincture. Our findings demonstrated that reserpine caused a marked increase on VCMs and the co-treatment with V. officinalis was able to reduce the intensity of VCM. Reserpine did not induce oxidative stress in cerebral structures (cortex, hippocampus, striatum and substantia nigra). However, a significant positive correlation between DCF-oxidation (an estimation of oxidative stress) in the cortex and VCMs (p < 0.05) was observed. Moreover, a negative correlation between Na+K+-ATPase activity in substantia nigra and the number of VCMs was observed (p < 0.05). In conclusion, V. officinalis had behavioral protective effect against reserpine-induced VCMs in rats; however, the exact mechanisms that contributed to this effect have not been completely understood.


Oral dyskinesia Parkinson’s disease Reserpine Vacuous chewing movements Valeriana officinalis 


Tardive dyskinesia


Parkinson’s disease


Vacuous chewing movements


Orofacial dyskinesia




Valeriana officinalis

V. officinalis

Reactive oxygen species


2′,7′-Dichlorodihydrofluorescein diacetate


Thiobarbituric acid reactive substances



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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Romaiana Picada Pereira
    • 1
    • 5
  • Roselei Fachinetto
    • 4
    • 5
  • Alessandro de Souza Prestes
    • 1
  • Caroline Wagner
    • 1
  • Jéssie Haigert Sudati
    • 1
  • Aline Augusti Boligon
    • 2
  • Margareth Linde Athayde
    • 2
  • Vera Maria Morsch
    • 1
  • João Batista Teixeira Rocha
    • 1
    • 3
    • 5
  1. 1.Departamento de Química, Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa MariaSanta MariaBrazil
  2. 2.Departamento de Farmácia IndustrialUniversidade Federal de Santa MariaSanta MariaBrazil
  3. 3.Abdus Salam International Centre for Theoretical PhysicsTriesteItaly
  4. 4.Departamento de Fisiologia e Farmacologia, Programa de Pós-Graduação em Farmacologia, and Programa de Pós-Graduação em Bioquímica ToxicológicaUniversidade Federal de Santa MariaSanta MariaBrazil
  5. 5.Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica ToxicológicaSanta MariaBrazil

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