Journal of Neural Transmission

, Volume 118, Issue 3, pp 337–347 | Cite as

A possible role for secreted ferritin in tissue iron distribution

  • Esther G. Meyron-Holtz
  • Shirly Moshe-Belizowski
  • Lyora A. Cohen
Basic Neurosciences, Genetics and Immunology - Review Article

Abstract

Ferritin is known as a well-conserved iron detoxification and storage protein that is found in the cytosol of many prokaryotic and eukaryotic organisms. In insects and worms, ferritin has evolved into a classically secreted protein that transports iron systemically. Mammalian ferritins are found intracellularly in the cytosol, as well as in the nucleus, the endo-lysosomal compartment and the mitochondria. Extracellular ferritin is found in fluids such as serum and synovial and cerebrospinal fluids. We recently characterized the biophysical properties, secretion mechanism and cellular origin of mouse serum ferritin, which is actively secreted by a non-classical pathway involving lysosomal processing. Here, we review the data to support a hypothesis that intracellular and extracellular ferritin may play a role in intra- and intercellular redistribution of iron.

Keywords

Extracellular ferritin Iron trafficking Serum ferritin Secretory lysosome 

Notes

Acknowledgments

We thank the organizers of the symposium on “Iron in Brain Function and Neurodegenerative Disorders” in honor of Moussa Youdim’s 70th birthday, S. Mandel, P. Riederer and E. Gruenblatt for putting together an outstanding program that inspired us to write this contribution. Our thanks are also due to Fanis Missirlis and Marianna Truman for critical reading, and to the US–Israel Binational Science Foundation, Grant #2007466 to Esther Meyron-Holtz and Tracey Rouault for financial support.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Esther G. Meyron-Holtz
    • 1
  • Shirly Moshe-Belizowski
    • 1
  • Lyora A. Cohen
    • 1
  1. 1.Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, TechnionTechnion City, HaifaIsrael

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