Journal of Neural Transmission

, Volume 118, Issue 4, pp 549–553

Micrographia induced by pallidal DBS for segmental dystonia: a subtle sign of hypokinesia?

  • Christian Blahak
  • Hans-Holger Capelle
  • Hansjoerg Baezner
  • Thomas M. Kinfe
  • Michael G. Hennerici
  • Joachim K. Krauss
Movement Disorders - Short Communication

Abstract

Recently parkinsonism has been reported as a rare side effect of globus pallidus internus (GPi) deep brain stimulation (DBS) for dystonia. In the present systematic prospective study in 11 patients with segmental dystonia not affecting distal arm function, we could demonstrate significant changes in handwriting characterized by mild micrographia following GPi-DBS. We propose that this finding reflects GPi-DBS-induced disturbances of basal ganglia function in terms of a mild hypokinetic syndrome, as a result of outflow alterations in pallido-thalamo-cortical pathways.

Keywords

Dystonia Deep brain stimulation Globus pallidus internus Micrographia Hypokinesia 

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Christian Blahak
    • 1
  • Hans-Holger Capelle
    • 2
  • Hansjoerg Baezner
    • 1
  • Thomas M. Kinfe
    • 2
  • Michael G. Hennerici
    • 1
  • Joachim K. Krauss
    • 2
  1. 1.Department of Neurology, Universitaetsmedizin Mannheim, UMMUniversity of HeidelbergMannheimGermany
  2. 2.Department of NeurosurgeryMedical School Hannover, MHHHannoverGermany

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