Journal of Neural Transmission

, Volume 117, Issue 9, pp 1119–1122

Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders

  • M. Takebayashi
  • R. Hashimoto
  • K. Hisaoka
  • M. Tsuchioka
  • H. Kunugi
Biological Psychiatry - Short Communication

Abstract

We investigated the plasma levels of VEGF and FGF-2, important factors for regulation of neuroplasticity such as neurogenesis, in patients in remission from major depressive disorders (MDD). The plasma VEGF levels were significantly higher in the MDD patients than in the matched control subjects, while no significant difference in plasma FGF-2 levels was found. In particular, the MDD patients with family history of psychiatric disorders, but not patients without such a family history, showed significantly higher values of plasma VEGF than the controls. Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD.

Keywords

VEGF FGF-2 Plasma Family history Mood disorders 

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • M. Takebayashi
    • 1
    • 2
  • R. Hashimoto
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • K. Hisaoka
    • 2
  • M. Tsuchioka
    • 2
  • H. Kunugi
    • 3
    • 8
  1. 1.Department of PsychiatryNational Hospital Organization (NHO) Kure Medical CenterKureJapan
  2. 2.Division of Psychiatry and Neuroscience, Institute for Clinical ResearchNHO Kure Medical CenterKureJapan
  3. 3.Department of Mental Disorder Research, National Institute of NeuroscienceNational Center of Neurology and Psychiatry (NCNP)TokyoJapan
  4. 4.Molecular Research Center for Children’s Mental Development, United Graduate School of Child DevelopmentOsaka UniversityOsakaJapan
  5. 5.Kanazawa University School of MedicineKanazawaJapan
  6. 6.Hamamatsu University School of MedicineHamamatsuJapan
  7. 7.Department of PsychiatryOsaka University Graduate School of MedicineOsakaJapan
  8. 8.JST, CRESTTokyoJapan

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