Journal of Neural Transmission

, Volume 117, Issue 9, pp 1119–1122 | Cite as

Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders

  • M. TakebayashiEmail author
  • R. Hashimoto
  • K. Hisaoka
  • M. Tsuchioka
  • H. Kunugi
Biological Psychiatry - Short Communication


We investigated the plasma levels of VEGF and FGF-2, important factors for regulation of neuroplasticity such as neurogenesis, in patients in remission from major depressive disorders (MDD). The plasma VEGF levels were significantly higher in the MDD patients than in the matched control subjects, while no significant difference in plasma FGF-2 levels was found. In particular, the MDD patients with family history of psychiatric disorders, but not patients without such a family history, showed significantly higher values of plasma VEGF than the controls. Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD.


VEGF FGF-2 Plasma Family history Mood disorders 



This study was supported by the Research Grants for Nervous and Mental Disorders from the NCNP, Health and Labor Sciences Research Grants (Research on Psychiatric and Neurological Diseases and Mental Health), a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), and JST, CREST.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • M. Takebayashi
    • 1
    • 2
    Email author
  • R. Hashimoto
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • K. Hisaoka
    • 2
  • M. Tsuchioka
    • 2
  • H. Kunugi
    • 3
    • 8
  1. 1.Department of PsychiatryNational Hospital Organization (NHO) Kure Medical CenterKureJapan
  2. 2.Division of Psychiatry and Neuroscience, Institute for Clinical ResearchNHO Kure Medical CenterKureJapan
  3. 3.Department of Mental Disorder Research, National Institute of NeuroscienceNational Center of Neurology and Psychiatry (NCNP)TokyoJapan
  4. 4.Molecular Research Center for Children’s Mental Development, United Graduate School of Child DevelopmentOsaka UniversityOsakaJapan
  5. 5.Kanazawa University School of MedicineKanazawaJapan
  6. 6.Hamamatsu University School of MedicineHamamatsuJapan
  7. 7.Department of PsychiatryOsaka University Graduate School of MedicineOsakaJapan
  8. 8.JST, CRESTTokyoJapan

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