Journal of Neural Transmission

, Volume 117, Issue 9, pp 1115–1117 | Cite as

Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia

  • Chen Zhang
  • Bin Xie
  • Yasong Du
  • Wenhong Cheng
  • Yiru Fang
  • Shunying Yu
Biological Psychiatry - Short Communication


Previous work suggests that the methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08–1.79). This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.


Case–control study MTHFR Schizophrenia 



The authors are very grateful to all participants. This work was supported by National Natural Science Foundation of China (30500181) and Shanghai Natural Science Foundation (10ZR1425700). We thank the three anonymous reviewers for their insightful comments.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Shanghai Mental Health CenterShanghai Jiaotong University School of MedicineShanghaiPeople’s Republic of China

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