Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia
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Previous work suggests that the methylenetetrahydrofolate reductase gene (MTHFR) functional polymorphism A1298C may be a risk factor for schizophrenia. In this study, the genetic association between the MTHFR A1298C polymorphism and schizophrenia was investigated in 379 patients with schizophrenia and 380 age- and sex-matched controls subjects. The results showed an association between the 1298C allele and the disorder (OR 1.39, 95% confidence interval 1.08–1.79). This provides further evidence that the MTHFR A1298C polymorphism may play a role in conferring risk for schizophrenia in the Chinese Han population.
KeywordsCase–control study MTHFR Schizophrenia
The authors are very grateful to all participants. This work was supported by National Natural Science Foundation of China (30500181) and Shanghai Natural Science Foundation (10ZR1425700). We thank the three anonymous reviewers for their insightful comments.
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