Journal of Neural Transmission

, Volume 117, Issue 7, pp 819–826 | Cite as

Time-dependent behavioral recovery after pneumococcal meningitis in rats

  • Tatiana Barichello
  • Geruza Z. Silva
  • Jaqueline S. Generoso
  • Geovana D. Savi
  • Cleonice M. Michelon
  • Gustavo Feier
  • Clarissa M. Comim
  • João Quevedo
Basic Neurosciences, Genetics and Immunology - Original Article
First Online:
Received:
Accepted:

Abstract

Alterations in hippocampus frequently occur following bacterial meningitis, despite antibiotic treatment. We investigated the cognitive performance in rats submitted to bacterial meningitis after 10, 30, and 60 days. To this aim, we utilized male Wistar rats submitted to either sham (control) or meningitis by Streptococcus pneumoniae, and followed by the initiation of the antibiotic treatment at 16 h after inoculation. The animals underwent six behavioral tasks 10, 30 and 60 days after surgery. We demonstrated that some of the learning and memory impairment, demonstrated 10 days after the induction of meningitis, persists up to 30 days, but not 60 days after induction.

Keywords

Learning Memory Depression Anxiety Central nervous system Meningitis 
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Notes

Acknowledgments

This research was supported by grants from CNPq (TB and JQ), FAPESC (TB and JQ) and UNESC (TB and JQ). JQ is a CNPq Research Fellows. CMC is holder of a CNPq Studentship.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Tatiana Barichello
    • 1
    • 4
  • Geruza Z. Silva
    • 1
  • Jaqueline S. Generoso
    • 1
  • Geovana D. Savi
    • 1
  • Cleonice M. Michelon
    • 1
  • Gustavo Feier
    • 2
  • Clarissa M. Comim
    • 2
  • João Quevedo
    • 2
    • 3
  1. 1.Laboratory of Microbiology and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, Health Sciences UnitUniversity of Southern Santa CatarinaCriciúmaBrazil
  2. 2.Laboratory of Neurosciences and National Institute for Translational Medicine, Postgraduate Program in Health Sciences, Health Sciences UnitUniversity of Southern Santa CatarinaCriciúmaBrazil
  3. 3.Laboratory of Translational PsychiatryResearch Center, Hospital São JoséCriciúmaBrazil
  4. 4.Laboratório de Fisiopatologia ExperimentalPPGCS, UNASAU, Universidade do Extremo Sul CatarinenseCriciúmaBrazil

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