Journal of Neural Transmission

, Volume 116, Issue 1, pp 89–95

Serotonin-induced decrease of intracellular Ca2+ release in platelets of bulimic patients normalizes during treatment

  • Lars Wöckel
  • Florian Daniel Zepf
  • Sabrina Koch
  • Anikó-Eva Meyer-Keitel
  • Martin H. Schmidt
Biological Psychiatry - Original Article

Abstract

Numerous symptoms related to eating disorders have been shown to be influenced by serotonergic (5-HT) functioning, with the 5-HT2A receptor subtype being one of the most relevant involved in the pathophysiology of bulimia nervosa (BN). In line with this, Ca2+ mobilization as mediated by 5-HT2 receptors in platelets was shown to serve as a peripheral model for central nervous 5-HT functioning. Here, the 5-HT-induced intracellular Ca2+ mobilization in platelets was measured in 13 female normal weight bulimic patients (14–18 years) upon admission and at the end of inpatient treatment. Findings were compared to 21 age-matched healthy female adolescents. 5-HT-induced Ca2+ release was significantly decreased in bulimic patients upon admission and normalized during inpatient treatment. Antidepressive medication caused a significant improvement. The data provide further evidence that altered 5-HT2 receptor functioning is involved in the pathophysiological underpinnings in BN.

Keywords

Serotonin Intracellular calcium Platelets Bulimia nervosa Antidepressants 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Lars Wöckel
    • 1
    • 3
  • Florian Daniel Zepf
    • 2
  • Sabrina Koch
    • 4
  • Anikó-Eva Meyer-Keitel
    • 3
  • Martin H. Schmidt
    • 3
  1. 1.Department of Child and Adolescent Psychiatry and PsychotherapyRWTH Aachen UniversityAachenGermany
  2. 2.Department of Child and Adolescent Psychiatry and Psychotherapy, University HospitalJohann Wolfgang Goethe-University of Frankfurt am MainFrankfurt am MainGermany
  3. 3.Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental HealthRuprecht-Karls-University of HeidelbergMannheimGermany
  4. 4.Department of Psychopharmacology, Central Institute of Mental HealthRuprecht-Karls-University of HeidelbergMannheimGermany

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