Journal of Neural Transmission

, Volume 115, Issue 11, pp 1573–1585

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

  • Klaus-Peter Lesch
  • Nina Timmesfeld
  • Tobias J. Renner
  • Rebecca Halperin
  • Christoph Röser
  • T. Trang Nguyen
  • David W. Craig
  • Jasmin Romanos
  • Monika Heine
  • Jobst Meyer
  • Christine Freitag
  • Andreas Warnke
  • Marcel Romanos
  • Helmut Schäfer
  • Susanne Walitza
  • Andreas Reif
  • Dietrich A. Stephan
  • Christian Jacob
Biological Psychiatry - Rapid Communication

DOI: 10.1007/s00702-008-0119-3

Cite this article as:
Lesch, KP., Timmesfeld, N., Renner, T.J. et al. J Neural Transm (2008) 115: 1573. doi:10.1007/s00702-008-0119-3

Abstract

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing ~500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

Keywords

Attention-deficit/hyperactivity disorder Adult ADHD Drug abuse Substance use disorder Genome-wide association GWA Pooled DNA 500K SNP array 50K SNP array Linkage Candidate genes Cell adhesion Signal transduction Synaptic plasticity 

Supplementary material

702_2008_119_MOESM1_ESM.doc (601 kb)
Supplementary materials (DOC 601 kb)
702_2008_119_MOESM2_ESM.pdf (2 mb)
Supplementary materials (PDF 1.96 mb)

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Klaus-Peter Lesch
    • 1
  • Nina Timmesfeld
    • 5
  • Tobias J. Renner
    • 2
  • Rebecca Halperin
    • 6
  • Christoph Röser
    • 1
  • T. Trang Nguyen
    • 5
  • David W. Craig
    • 6
  • Jasmin Romanos
    • 1
    • 2
  • Monika Heine
    • 1
  • Jobst Meyer
    • 3
  • Christine Freitag
    • 4
  • Andreas Warnke
    • 2
  • Marcel Romanos
    • 2
  • Helmut Schäfer
    • 5
  • Susanne Walitza
    • 2
  • Andreas Reif
    • 1
  • Dietrich A. Stephan
    • 6
  • Christian Jacob
    • 1
  1. 1.ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and PsychotherapyUniversity of WuerzburgWuerzburgGermany
  2. 2.ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyUniversity of WuerzburgWuerzburgGermany
  3. 3.Department of Neurobehavioral GeneticsUniversity of TrierTrierGermany
  4. 4.Department of Child and Adolescent PsychiatrySaarland University HospitalHomburgGermany
  5. 5.Institute of Medical Biometry and EpidemiologyUniversity of MarburgMarburgGermany
  6. 6.Neurogenomics Division, TGenThe Translational Genomics Research InstitutePhoenixUSA

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