The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.
Early-onset Parkinson’s disease LRRK2 Gly2385Arg mutation Chinese
We are indebted to the valuable support and advice from Prof. Richard Kay. Ethical standards: Ethics application were applied for and obtained by the Chinese University of Hong Kong. Informed consents were obtained from all participants.
Berg D, Schweitzer K, Leitner P et al (2005) Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson’s disease. Brain 128:3000–3011PubMedGoogle Scholar
Cao L, Zhang T, Xiao Q et al (2007) The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson’s disease. Mov Disord 22:2439–2442CrossRefGoogle Scholar
Chan DKY, Cordato D, Triet Bui, Mellick G (2004) Comparison of environmental and genetic factors for Parkinson’s disease between Chinese and Caucasians. Neuroepidemiology 23:13–22PubMedCrossRefGoogle Scholar
Chan DKY, Mok V, Ng PW et al (2008) PARK2 mutations and clinical features in a Chinese population with early onset Parkinson’s disease. J Neural Transm doi 10.1007/s00702-007-0011-6
Di Fonzo A, Wu-Chou YH, Lu CS et al (2006) A common missense variant in the LRRK2 gene, Gly2385Arg, associated with parkinson’s diseae risk in Taiwan. Neurogenetics 7:133–138PubMedCrossRefGoogle Scholar
Funayama M, Li Y, Tomiyama H et al (2007) Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population. NeuroReport 18:273–275PubMedCrossRefGoogle Scholar
Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR (2006) A common genetic factor for Parkinson’s disease in ethnic Chinese population in Taiwan. BMC Neurol 6:47PubMedCrossRefGoogle Scholar
Gilks WP, Abou-Sleiman PM, Gandhi S et al (2005) A common LRRK2 mutation in idiopathic Parkinson’s disease. Lancet 365(9457):415–416PubMedGoogle Scholar