Journal of Neural Transmission

, Volume 115, Issue 9, pp 1275–1277 | Cite as

LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients

  • Daniel Kam Yin Chan
  • Ping Wing Ng
  • Vincent Mok
  • Jonas Yeung
  • Zhi Ming Fang
  • Raymond Clarke
  • Edward Leung
  • Lawrence Wong
Basic Neurosciences, Genetics and Immunology - Short Communication

Abstract

The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age ≤45 years) Parkinson’s disease was identified and compared with late-onset patients (age >50 years) and controls. The mutation prevalence were 8.8, 8.3, and 0% for early-onset, late-onset, and controls, respectively. The mean age of onset among LRRK2 G2385R carriers was 42.7 years old for early-onset compared to 74.3 for late-onset patients. LRRK2 G2385R mutation appears to be as prevalent among early-onset as late-onset patients.

Keywords

Early-onset Parkinson’s disease LRRK2 Gly2385Arg mutation Chinese 

Notes

Acknowledgments

We are indebted to the valuable support and advice from Prof. Richard Kay. Ethical standards: Ethics application were applied for and obtained by the Chinese University of Hong Kong. Informed consents were obtained from all participants.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Daniel Kam Yin Chan
    • 1
    • 2
  • Ping Wing Ng
    • 3
  • Vincent Mok
    • 4
  • Jonas Yeung
    • 5
  • Zhi Ming Fang
    • 6
  • Raymond Clarke
    • 6
  • Edward Leung
    • 3
  • Lawrence Wong
    • 4
  1. 1.Department of Aged Care and RehabilitationBankstown-Lidcombe HospitalBankstownAustralia
  2. 2.Faculty of MedicineUniversity of New South WalesKensingtonAustralia
  3. 3.Department of Medicine and GeriatricsUnited Christian HospitalHong Kong SARPeople’s Republic of China
  4. 4.Neurology Division, Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongHong Kong SARPeople’s Republic of China
  5. 5.Department of MedicineAHML Nethersole HospitalHong Kong SARPeople’s Republic of China
  6. 6.Cancer Care CentreSt George HospitalKogarahAustralia

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