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Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT

  • Chittaranjan AndradeEmail author
  • Shivashanmugam Thyagarajan
  • Nagendra Madan Singh
  • Pabbisetty S. Vinod
  • N. Sanjay Kumar Rao
  • J. Suresh Chandra
Biological Psychiatry - Original Article

Abstract

Background

Cyclooxygenase-2 (COX-2) mechanisms are involved in glutamate-mediated learning and memory as well as in glutamatergic excitotoxicity. Electroconvulsive therapy (ECT)-induced amnesia may arise from glutamatergic excitotoxicity; if so, COX-2 inhibition may attenuate retrograde amnesia with ECT.

Methods

Wistar rats which received celecoxib (15 mg/kg per day) or vehicle for 18 days were trained for 3 days on a passive avoidance task. On each of the next 3 days, rats which showed perfect learning (n = 51) received true or sham suprathreshold electroconvulsive shocks (ECS; 60 mC) in a factorial design; daily dosing with drug or vehicle was continued. One day after the last ECS, recall of pre-ECS learning was tested.

Results

ECS-treated rats showed impaired recall in the vehicle but not celecoxib group. Celecoxib significantly protected against ECS-induced retrograde amnesia; this benefit was independent of the drug-induced attenuation of ECS seizure duration.

Conclusions

Celecoxib may protect against ECS-induced retrograde amnesia by attenuating ECS-induced, COX-2-mediated glutamatergic excitotoxicity.

Keywords

Electroconvulsive therapy Learning Memory Celecoxib COX-2 Glutamate 

Notes

Acknowledgments

Author S. Thyagarajan was supported by an unrestricted grant from the non-profit Scion Natural Science Association, St James, New York, USA.

Conflict of interest statement

There are no financial or other conflicts of interest except as stated in the acknowledgement.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Chittaranjan Andrade
    • 1
    Email author
  • Shivashanmugam Thyagarajan
    • 1
  • Nagendra Madan Singh
    • 1
  • Pabbisetty S. Vinod
    • 1
  • N. Sanjay Kumar Rao
    • 2
  • J. Suresh Chandra
    • 3
  1. 1.Department of PsychopharmacologyNational Institute of Mental Health and NeurosciencesBangaloreIndia
  2. 2.Consultant Liaison Psychiatrist and Clinical Lead, The Logos Centre for Cognitive Behavioural Therapy and Mental Health PromotionTees Esk and Wear Valley NHS Trust, County HospitalDurhamUK
  3. 3.Senior Veterinarian, Central Animal Research FacilityNational Institute of Mental Health and NeurosciencesBangaloreIndia

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