Journal of Neural Transmission

, Volume 115, Issue 9, pp 1321–1325 | Cite as

Investigation of the functional brain-derived neurotrophic factor gene variant Val66MET in migraine

  • Martin Marziniak
  • Andrea Herzog
  • Rainald Mössner
  • Claudia Sommer
Basic Neurosciences, Genetics and Immunology - Original Article

Abstract

Experimental studies and investigations of the cerebrospinal fluid in migraineurs have suggested an involvement of brain-derived neurotrophic factor (BDNF) in migraine pathophysiology. In a case–control study approach, the functional Val66MET polymorphism (rs6265) of the BDNF gene was investigated in 265 migraine patients and 153 controls. Genotype and allele frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphism. Our data argue against a role of this well characterized BDNF gene variant as a risk factor in migraine.

Keywords

Brain-derived neurotrophic factor Polymorphism Migraine Calcitonin-gene-related peptide 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Martin Marziniak
    • 1
    • 2
    • 3
  • Andrea Herzog
    • 4
  • Rainald Mössner
    • 4
    • 5
  • Claudia Sommer
    • 1
  1. 1.Department of NeurologyUniversity of WürzburgWürzburgGermany
  2. 2.Department of NeurologySaarland UniversityHomburg/SaarGermany
  3. 3.Department of NeurologyUniversity of MünsterMünsterGermany
  4. 4.Department of Psychiatry and PsychotherapyUniversity of WürzburgWürzburgGermany
  5. 5.Department of Psychiatry and PsychotherapyUniversity of BonnBonnGermany

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